Results 21 to 30 of about 29,695 (266)
Cell Communication and Signaling, 2023 Background The Philadelphia chromosome encodes the BCR-ABL fusion protein, which has two primary subtypes, P210 and P190. P210 and P190 cause Philadelphia-positive chronic myeloid leukemia (Ph+ CML) and Philadelphia-positive acute lymphoblastic leukemia (
Run Qin +6 more
doaj +1 more source
STAT6-driven immunity decreases N. brasiliensis reproductive output and survival within host.
, 2023 A. Experimental evolution design, N. brasiliensis (originally isolated from rat host, brown) were infected for several generations (n) through either WT (black or gray) or STAT6 KO (red) mouse hosts to produce adapted cohorts. Data in this figure is from
Quentin Gouil (3594686) +13 more
core +1 more source
Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi's Sarcoma-Associated Herpesvirus for Viral Latency. [PDF]
PLoS Pathogens, 2017 Emerging evidence implies that STAT6 plays an important role in both the adaptive and innate immune responses to virus infection. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus agent associated with several human ...
Chong Wang +12 more
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Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy
Pharmaceutics, 2020 Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration.
Emanuela Fabiola Craparo +4 more
doaj +1 more source
Anti-STAT6 CTL activity inStat6−/−mice [PDF]
JAK-STAT, 2013 The generation of germline gene mutations in mice has been an invaluable tool for experimental biology. However, studying immune responses that develop in the absence of a specific protein that could alter thymic selection complicates experimental interpretations. We observed that CD8(+) T cells from Stat6 (-/-) mice displayed "autoreactivity" to STAT6-
Kaplan, Mark H. +3 more
openaire +2 more sources
Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. [PDF]
, 2013 BACKGROUND: Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood.
Meira, LB +32 more
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STAT6 - regulierte B-Zell-Antworten [PDF]
, 2022 IL-4 engagement of IL-4R type I results in tyrosine phosphorylation of janus kinase (JAK) 1 and 3. Activated JAKs phosphorylate STAT6, which dimerizes and translocates to the nucleus of B cells to regulate target gene expression important for IgE class ...
Mokada-Gopal, Lavanya
core +1 more source
Case Reports in Oncology, 2023 Solitary fibrous tumors (SFTs) are soft tumors (mesenchymal origin) that most likely develop from adult mesenchymal stem cells. SFTs are not common in the head and neck region, and the characteristics of tumors in this location are unclear.
Kensuke Suzuki +5 more
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Медицинская иммунология, 2014 . The review article summarizes current information about transcriptional factors Fохр3, GATA- 3, РАХ-5 and their cooperative interactions. Predomination of one of these factors leads to production of corresponding cytokines and appropriate changes in T ...
V. N. Mineev +4 more
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Медицинская иммунология, 2014 . The aim of the study is to specify the levels of STAT6, and phospho-STAT6 under the influence of IL-4 in patients with bronchial asthma (BA). The samples from ten healthy controls and thirty-three BA patients with allergic and non-allergic clinical ...
V. N. Mineev +2 more
doaj +1 more source