Results 21 to 30 of about 30,689 (278)

Head and Neck Solitary Fibrous Tumor Presenting as Salivary Gland Tumor: Two Case Reports and Review of the Literature

Case Reports in Oncology, 2023
Solitary fibrous tumors (SFTs) are soft tumors (mesenchymal origin) that most likely develop from adult mesenchymal stem cells. SFTs are not common in the head and neck region, and the characteristics of tumors in this location are unclear.
Kensuke Suzuki, Yuri Noda, Tomofumi Sakagami, Masao Yagi, Kimihide Kusafuka, Hiroshi Iwai   +5 more
doaj   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium-Dependent ANXA2⁺sEVs Driving M2 Polarization of TAMs. [PDF]

Adv Sci (Weinh)
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Fang Y, Zhu J, Xiao Q, Wei Q, He X, Li P, Jiang K, Liu Y, Hu Y, Yu W, Guo C, Chen S, Zhao J, Dai S, Wei J, Yang H, Bu T, Ding K, Chen H.   +18 more
europepmc   +2 more sources

Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. [PDF]

, 2013
BACKGROUND: Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood.
Meira, LB, Czimmerer, Z, Louise M Brignull, Hafida Saidi, Saidi, H, Bartlett, Nathan W., Bence Daniel, Nagy, László, Villela, Izabel, Nohturfft, A, Brignull, LM, Izabel Villela, Johnston, Sebastian L., Meira, Lisiane B., Villela, I, Axel Nohturfft, Nohturfft, Axel, Zsolt Czimmerer, Brignull, L. M., Nathan W Bartlett, Saidi, H., Dániel, Bence, Czimmerer, Zsolt, Daniel, B, Lisiane B Meira, Saidi, Hafida, Brignull, Louise M., Nagy, L, Villela, I., Laszlo Nagy, Bartlett, NW, Johnston, SL, Sebastian L Johnston   +32 more
core   +1 more source

Anti-STAT6 CTL activity inStat6^−/−mice [PDF]

JAK-STAT, 2013
The generation of germline gene mutations in mice has been an invaluable tool for experimental biology. However, studying immune responses that develop in the absence of a specific protein that could alter thymic selection complicates experimental interpretations. We observed that CD8(+) T cells from Stat6 (-/-) mice displayed "autoreactivity" to STAT6-
Kaplan, Mark H., Cundiff, Judy K., Smith, Jill Stader, Aldrich, Carla J.   +3 more
openaire   +2 more sources

A rare case of a solitary fibrous tumor of vulva, displaying NAB2ex6-STAT6ex17 fusion

Indian Journal of Pathology and Microbiology, 2021
A solitary fibrous tumor (SFT), although ubiquitous, is rarely documented in the female genital tract, especially confirmed by STAT6 immunostaining and underlying NAB2-STAT6 gene fusion.
Bharat Rekhi, Prachi Bapat, Arpita Jindal   +2 more
doaj   +1 more source

Functional expression of STAT6 in macrophages of the Mac-STAT6 mouse.

, 2023
Bone marrow derived macrophages (BMDM, purity >95%) were generated and splenic B cells (purity > 90%) isolated from mice that do express STAT6 only under control of the LysMCre promoter (Mac-STAT6), STAT6 knockout mice (STAT6ko) and BALB/c wild-type (WT)
Daniel Radtke (6190244), David Voehringer (713702), Kirstin Castiglione (15188308), Stefanie Westermann (15188305), Christoph Schubart (441046), Axel Dietschmann (4103692)   +5 more
core   +1 more source

TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA

Медицинская иммунология, 2014
. The review article summarizes current information about transcriptional factors Fохр3, GATA- 3, РАХ-5 and their cooperative interactions. Predomination of one of these factors leads to production of corresponding cytokines and appropriate changes in T ...
V. N. Mineev, L. N. Sorokina, A. V. Eremeeva, M. A. Nyoma, A. S. Bedenko   +4 more
doaj   +1 more source

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics [PDF]

, 2016
Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that ...
van Laar, Jacob, Van Laar, Jacob M., O'Reilly, Steven, Fullard, Nicola, Ciechomska, Marzena, Przyborski, Stefan, van Laar, J.M., O’Reilly, S., Fullard, N., Przyborski, S., Ciechomska, M., Infection & Immunity, MS Reumatologie/Immunologie/Infectie   +12 more
core   +1 more source

STAT6-driven immunity decreases N. brasiliensis reproductive output and survival within host.

, 2023
A. Experimental evolution design, N. brasiliensis (originally isolated from rat host, brown) were infected for several generations (n) through either WT (black or gray) or STAT6 KO (red) mouse hosts to produce adapted cohorts. Data in this figure is from
Quentin Gouil (3594686), Louise Baker (558789), Adler R. Dillman (8374437), Aaron R. Jex (11185801), Juan M. Inclan-Rico (8856584), Erich M. Schwarz (17427398), De’Broski R. Herbert (10742888), Matthew E. Ritchie (11604186), LiYin Hung (17616292), Heather L. Rossi (11576963), Annabel A. Ferguson (17616286), Meera G. Nair (11152209), Dihong Lu (3612917), Sarah D. Bobardt (17616289)   +13 more
core   +1 more source

Solitary fibrous tumor/hemangiopericytoma of the external auditory canal

Acta Oto-Laryngologica Case Reports, 2019
Introduction: Solitary fibrous tumor/hemangiopericytoma is an uncommon neoplasm that accounts for only 1–2% of all soft tissue tumors. To the best of our knowledge only three cases of this tumor have been described in the external auditory canal in the ...
Jefferson Rijo-Cedeño, Luz Martín-Figueiro, Harold Tavárez, Rafael Ramírez-Camacho   +3 more
doaj   +1 more source