Results 41 to 50 of about 30,689 (278)
Frontiers in Immunology, 2021 B cells could convert naïve T cells into regulatory T cells (so-called Treg-of-B cells) which have the ability to treat animal models of inflammatory diseases, including allergic asthma, collagen-induced arthritis and colitis; however, the mechanisms of ...
Kuan-Hua Chu +5 more
doaj +1 more source
Mutational Analysis of the STAT6 SH2 Domain [PDF]
Journal of Biological Chemistry, 1998 The SH2 domain of the STAT family of transcription factors is essential for STAT binding to phosphorylated cytoplasmic domains of activated cytokine receptors. Furthermore, the same domain mediates dimerization of activated STAT monomers, a prerequisite for DNA binding by this family of proteins.
T, Mikita +3 more
openaire +2 more sources
Activating STAT6 mutations in follicular lymphoma [PDF]
Blood, 2015 Key Points FL-associated STAT6 mutations hyperactivate the IL-4/JAK/STAT6 axis.
Mehmet, Yildiz +13 more
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Neoplasia: An International Journal for Oncology Research, 2017 Intestinal tumorigenesis in the ApcMin/+ model is initiated by aberrant activation of Wnt pathway. Increased IL-4 expression in human colorectal cancer tissue and growth of colon cancer cell lines implied that IL-4–induced Stat6-mediated tumorigenic ...
Asha Jayakumar, Alfred L.M. Bothwell
doaj +1 more source
Regression of a Mammary Adenocarcinoma in STAT6−/− Mice Is Dependent on the Presence of STAT6-Reactive T Cells [PDF]
The Journal of Immunology, 2003 Abstract Polarization of the immune response toward a type 1 cytokine profile has been posited to be associated with a therapeutic antitumor immune response. STAT6−/− mice are unable to generate a type 2 immune response, and instead mount an enhanced type 1 response.
Jensen, Shawn M. +5 more
openaire +3 more sources
STAT6 Mediates Interleukin-4 Growth Inhibition in Human Breast Cancer Cells
Neoplasia: An International Journal for Oncology Research, 2002 In addition to acting as a hematopoietic growth factor, interleukin-4 (IL-4) inhibits growth of some transformed cells in vitro and in vivo. In this study, we show that insulin receptor substrate (IRS)-1, IRS-2, and signal transducer and activator of ...
Jennifer L. Gooch +2 more
doaj +1 more source
STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway
Cell Death and Disease, 2022 Compelling evidences have revealed the emerging role of ferroptosis in the pathophysiological process of acute lung injury (ALI), but its modulation is not clear.
Youjing Yang +7 more
doaj +1 more source
STAT6 Signaling Mediates PPARγ Activation and Resolution of Acute Sterile Inflammation in Mice
Cells, 2021 The signal transducer and activator of transcription 6 (STAT6) transcription factor promotes activation of the peroxisome proliferator-activated receptor gamma (PPARγ) pathway in macrophages.
Ye-JI Lee +5 more
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Specific inhibition of Src-Tyrosine kinase reduces STAT6 activation.
, 2012 (A) Tip, Lck and STAT6 transfected 293T cells were treated with PP2 or the non-active control substance PP3 (10 µM in DMSO each). STAT6, pSTAT6, Tip and GAPDH were detected by fluorescent immunoblotting on the same membrane.
Armin Ensser (173680) +7 more
core +1 more source
STAT6 is cleaved by serine protease upon KSHV infection.
, 2017 (A) LANA promotes serine protease-mediated cleavage of STAT6. HEK293 cells co-transfected by FLAG-STAT6 with LANA-myc or vector alone were lysed in the absence or presence of different protease inhibitors as indicated, followed by immunoblotting against ...
Yuhong Li (448146) +12 more
core +1 more source