Results 41 to 50 of about 29,695 (266)
Journal of Urological Surgery, 2023 A solitary fibrous tumor (SFT) originating from the prostate has been rarely reported, presenting the 44th case. We evaluated a 44-year-old man who presented with a two-year history of pressure in the lower abdomen. On magnetic resonance imaging, a 48×66
Hasan Yılmaz +4 more
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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
iScience, 2022 Summary: Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics ...
Hyunmi Kim, Soo Jung Park, Ilo Jou
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Haematologica, 2009 Understanding the mechanisms behind malarial anemia should lead to new approaches to the management and treatment of children. In this perspective article Drs. Robson and Weatherall examine the pathophysiology of this condition. See related article on page 195.
Robson, K, Weatherall, D
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Association analysis of STAT6 SNP with asthma in Pakistani population
Pakistan Journal of Pharmaceutical Sciences, 2021 Signal transducer and activator of transcription 6 gene (STAT6) is an important player of inflammatory pathways. The role of single nucleotide polymorphisms (SNPs) of STAT6 to the risk of asthma or IgE has been studied in several populations. We examined
Ayesha Riaz +4 more
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Frontiers in Immunology, 2021 B cells could convert naïve T cells into regulatory T cells (so-called Treg-of-B cells) which have the ability to treat animal models of inflammatory diseases, including allergic asthma, collagen-induced arthritis and colitis; however, the mechanisms of ...
Kuan-Hua Chu +5 more
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Mutational Analysis of the STAT6 SH2 Domain [PDF]
Journal of Biological Chemistry, 1998 The SH2 domain of the STAT family of transcription factors is essential for STAT binding to phosphorylated cytoplasmic domains of activated cytokine receptors. Furthermore, the same domain mediates dimerization of activated STAT monomers, a prerequisite for DNA binding by this family of proteins.
T, Mikita +3 more
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Oncogenic Mutations and Tumor Microenvironment Alterations in Diffuse Large B-Cell Lymphoma With Bulky Disease. [PDF]
Cancer MedABSTRACT Background Bulky disease represents a clinically aggressive subset of diffuse large B‐cell lymphoma (DLBCL) associated with adverse clinical outcomes. The aim of this study was to investigate the influence of oncogenic mutations and tumor microenvironment alterations on bulky disease in DLBCL.
Wang YQ +11 more
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Activating STAT6 mutations in follicular lymphoma [PDF]
Blood, 2015 Key Points FL-associated STAT6 mutations hyperactivate the IL-4/JAK/STAT6 axis.
Mehmet, Yildiz +13 more
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Neoplasia: An International Journal for Oncology Research, 2017 Intestinal tumorigenesis in the ApcMin/+ model is initiated by aberrant activation of Wnt pathway. Increased IL-4 expression in human colorectal cancer tissue and growth of colon cancer cell lines implied that IL-4–induced Stat6-mediated tumorigenic ...
Asha Jayakumar, Alfred L.M. Bothwell
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Regression of a Mammary Adenocarcinoma in STAT6−/− Mice Is Dependent on the Presence of STAT6-Reactive T Cells [PDF]
The Journal of Immunology, 2003 Abstract Polarization of the immune response toward a type 1 cytokine profile has been posited to be associated with a therapeutic antitumor immune response. STAT6−/− mice are unable to generate a type 2 immune response, and instead mount an enhanced type 1 response.
Jensen, Shawn M. +5 more
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