Results 51 to 60 of about 29,695 (266)
p160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain [PDF]
, 2008 Transcriptional activation involves the ordered recruitment of coactivators via direct interactions between distinct binding domains and recognition motifs.
Coudevylle, N. +12 more
core +1 more source
Unexpected Phenotype of STAT6 Heterozygous Mice Implies Distinct STAT6 Dosage Requirements for Different IL-4 Functions [PDF]
, 2013 Background: STAT6 is an important transcription factor in interleukin-4 (IL-4) signaling, a key cytokine in atopic diseases and allergic asthma. STAT6 gene-targeted mice are unable to develop IgE and T helper 2 cell (Th2) responses in several models of ...
Bürgis, Susanne, Gessner, André
core +1 more source
Structural basis for DNA recognition by STAT6 [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance STAT6 is a transcription factor and plays a predominant role in IL-4/IL-13 and virus-mediated signaling pathways. Extensive studies have linked malfunctions of STAT6 to pathological features of asthma and cancer. Targeting the function of STAT6 has become an attractive therapy.
Jing, Li +17 more
openaire +2 more sources
STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway
Cell Death and Disease, 2022 Compelling evidences have revealed the emerging role of ferroptosis in the pathophysiological process of acute lung injury (ALI), but its modulation is not clear.
Youjing Yang +7 more
doaj +1 more source
STAT6 Signaling Mediates PPARγ Activation and Resolution of Acute Sterile Inflammation in Mice
Cells, 2021 The signal transducer and activator of transcription 6 (STAT6) transcription factor promotes activation of the peroxisome proliferator-activated receptor gamma (PPARγ) pathway in macrophages.
Ye-JI Lee +5 more
doaj +1 more source
, 2013 Decay of Stat6 activation in Ttc7-fsn B cells. Purified splenic B cells were stimulated with IL-4 for 30 minutes, washed 3X and allowed to rest for 15 or 30 minutes, then stained for Stat6 (red) and the nucleus (green) and imaged with confocal microscopy
Beth L. Hill (380277) +1 more
core +1 more source
Proteolytic Regulation of Activated STAT6 by Calpains [PDF]
The Journal of Immunology, 2005 Abstract The transcription factor STAT6 plays an important role in cell responses to IL-4. Its activation is tightly regulated. STAT6 phosphorylation is associated with JAKs, whereas dephosphorylation is associated with specific phosphatases. Several studies indicate that proteases can also regulate STAT6. The aim of this study was to
Jose, Zamorano +3 more
openaire +2 more sources
, 2013 Activation of Stat6 in Ttc7-fsn B cells. Purified splenic B cells were unstimulated (0) or stimulated with IL-4 for 15 and 30 minutes, then stained for Stat6 (red) and the nucleus (green) and visualized with confocal microscopy using a 60x objective.
Beth L. Hill (380277) +1 more
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
STAT6 siRNA sequences 1 and 4 significantly block STAT6 expression.
, 2019 (A) Measure of STAT6 mRNA level in HT-29 cells 24 hours post-transfection. The graph represents the mean ± SEM of multiple independent experiments (n) obtained by real-time PCR. Results were analysed by ΔΔCt method for relative quantifications.
Beatriz Canals-Lorente (6690050) +5 more
core +1 more source