Results 51 to 60 of about 30,689 (278)
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Proteolytic Regulation of Activated STAT6 by Calpains [PDF]
The Journal of Immunology, 2005 Abstract The transcription factor STAT6 plays an important role in cell responses to IL-4. Its activation is tightly regulated. STAT6 phosphorylation is associated with JAKs, whereas dephosphorylation is associated with specific phosphatases. Several studies indicate that proteases can also regulate STAT6. The aim of this study was to
Jose, Zamorano +3 more
openaire +2 more sources
Drug Design, Development and Therapy, 2020 Shuo Zhang,1,2 Wen-chong Sun,2 Zuo-di Liang,2 Xiu-ru Yin,2 Zhen-rong Ji,2 Xiao-huan Chen,2 Min-jie Wei,1 Ling Pei2 1Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110001, People’s Republic of China ...
Zhang S +7 more
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Unexpected Phenotype of STAT6 Heterozygous Mice Implies Distinct STAT6 Dosage Requirements for Different IL-4 Functions [PDF]
, 2013 Background: STAT6 is an important transcription factor in interleukin-4 (IL-4) signaling, a key cytokine in atopic diseases and allergic asthma. STAT6 gene-targeted mice are unable to develop IgE and T helper 2 cell (Th2) responses in several models of ...
Bürgis, Susanne, Gessner, André
core
Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling
, 2002 Udgivelsesdato: 2003-Jan-31Interleukin-4 (IL-4) plays a pivotal role in the induction and maintenance of allergy by promoting Th2 differentiation and B cell isotype switching to IgE. Studies on STAT6-deficient mice have demonstrated the essential role of
Lovato, Paola +8 more
core +1 more source
Advanced Science, EarlyView.A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao +7 more
wiley +1 more source
STAT6-Dependent Regulation of Th9 Development [PDF]
The Journal of Immunology, 2012 Abstract Th cell effector subsets develop in response to specific cytokine environments. The development of a particular cytokine-secreting pattern requires an integration of signals that may promote the development of opposing pathways.
Ritobrata, Goswami +6 more
openaire +2 more sources
Advanced Science, EarlyView.This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan +6 more
wiley +1 more source
Advanced Science, EarlyView.Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang +14 more
wiley +1 more source
STAT6 rs324015 Gene Polymorphism Increases Ulcerative Colitis Risk: A Case–Control Study
Pharmacogenomics and Personalized Medicine, 2021 Lingying Dai,1,* Dan Zhang,2,* Yunzhi Qian,2 Yemin Wan,2 Shuchen Chang,2 Haihua Qian2 1No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, People’s Republic of China; 2Department of Colorectal Surgery ...
Dai L +5 more
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