Results 71 to 80 of about 29,695 (266)

Disruption of STAT6 Signal Promotes Cardiac Fibrosis Through the Mobilization and Transformation of CD11b+ Immature Myeloid Cells

Frontiers in Physiology, 2020
Cardiac fibrosis is an important pathological basis of various cardiovascular diseases. The roles of STAT6 signal in allergy, immune regulation, tumorigenesis, and renal fibrosis have been documented.
Weiwei Zhang, Baoling Zhu, Baoling Zhu, Suling Ding, Xiangfei Wang, Xiangfei Wang, Jian Wu, Jian Wu, Xiaowei Zhu, Xiaowei Zhu, Yunzeng Zou, Yunzeng Zou, Junbo Ge, Junbo Ge, Minghong Tong, Xiangdong Yang, Xiangdong Yang   +16 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

STAT6 rs324015 Gene Polymorphism Increases Ulcerative Colitis Risk: A Case–Control Study

Pharmacogenomics and Personalized Medicine, 2021
Lingying Dai,1,* Dan Zhang,2,* Yunzhi Qian,2 Yemin Wan,2 Shuchen Chang,2 Haihua Qian2 1No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, People’s Republic of China; 2Department of Colorectal Surgery ...
Dai L, Zhang D, Qian Y, Wan Y, Chang S, Qian H   +5 more
doaj  

Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells.

PLoS ONE, 2020
Approximately 20% of breast cancers are HER2-positive. Trastuzumab has improved patient outcomes significantly for these cancers. However, acquired resistance remains a major hurdle in the clinical management of these patients.
Molly DiScala, Matthew S Najor, Timothy Yung, Deri Morgan, Abde M Abukhdeir, Melody A Cobleigh   +5 more
doaj   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

RTA interacts with STAT6.

, 2018
(A) Ectopic expression of exogenous STAT6 interacted with RTA. Whole cell lysate (WCL) from 293T cells co-transfected with different combination of FLAG-STAT6 and RTA-myc as indicated, were subjected to immunoprecipitation (IP) followed by immunoblotting
Ling Ding (302098), Chong Wang (120449), Qing Zhu (349093), Cankun Cai (6065465), Feng Gu (45619), Wenjia Xu (815857), Yuyan Wang (283747), Zhikang Qian (251624), Zhenghong Yuan (12153), Fang Wei (31236), Erle Robertson (209092), Caixia Zhu (344874), Qiliang Cai (180057)   +12 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

STAT6-deficient mice do not show any deficiency in Chlamydia clearance.

(A) IFUs isolated from vaginal swabs at various time points after infection. For wild-type mice n = 10, STAT6-deficient mice n = 10, and MHC class II-deficient mice n = 5.
Kevin D. Fong (17721439), Claire Morris (2019940), Jordan A. Rixon (12127234), Claire E. Depew (12127237), Stephen J. McSorley (9079957), Alana T. Nguyen (17721442)   +5 more
core   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source