Results 81 to 90 of about 29,695 (266)

STAT6 knockdown using multiple siRNA sequences inhibits proliferation and induces apoptosis of human colorectal and breast cancer cell lines.

PLoS ONE, 2019
The transcription factor STAT6 is strongly expressed in various tumours and is most highly expressed in human malignant lymphomas and pancreatic, colorectal, prostate and breast cancers.
Carmen Salguero-Aranda, Daniel Sancho-Mensat, Beatriz Canals-Lorente, Sabena Sultan, Ajan Reginald, Lee Chapman   +5 more
doaj   +1 more source

Bixin Protects Against Kidney Interstitial Fibrosis Through Promoting STAT6 Degradation

Frontiers in Cell and Developmental Biology, 2020
Bixin, a natural carotenoid extracted from the seeds of Bixa orellana, has antioxidant and anti-inflammation effects. However, the pharmacological effects and underlying mechanisms of bixin in kidney interstitial fibrosis remain unknown.
Jianzhong Li, Jianzhong Li, Youjing Yang, Shuhui Wei, Ling Chen, Lian Xue, Hailin Tian, Shasha Tao, Shasha Tao   +8 more
doaj   +1 more source

Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection.

PLoS Pathogens, 2023
Gastrointestinal helminths are a major health threat worldwide. Alternatively activated macrophages (AAMs) have been shown to contribute to host protection during secondary helminth infections. AAMs express effector molecules that depend on activation of
Stefanie Westermann, Christoph Schubart, Axel Dietschmann, Kirstin Castiglione, Daniel Radtke, David Voehringer   +5 more
doaj   +1 more source

KSHV induces STAT6 nuclear localization.

, 2017
(A) Confocal microscopy of endogenous STAT6 in iSLK stable cells with or without KSHV infection after puromycin selection. Nuclei were stained with DAPI. Scale bars represent 10μM.
Yuhong Li (448146), Chong Wang (120449), Shujun Gao (132959), Yin Tong (789660), Liming Zhang (213971), Jianqing Xu (135427), Erle S. Robertson (177370), Zhenghong Yuan (12153), Fang Wei (31236), Yanling Feng (294987), Bin Wang (30851), Caixia Zhu (344874), Qiliang Cai (180057)   +12 more
core   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines

Respiratory Research
Background Obstructive sleep apnea (OSA) is frequently associated with increased incidence and mortality of pulmonary hypertension (PH). The immune response contributes to pulmonary artery remodeling and OSA-related diseases.
Pan Jiang, Huai Huang, Zilong Liu, Guiling Xiang, Xiaodan Wu, Shengyu Hao, Shanqun Li   +6 more
doaj   +1 more source

STAT6 is cleaved by serine protease upon KSHV infection.

, 2017
(A) LANA promotes serine protease-mediated cleavage of STAT6. HEK293 cells co-transfected by FLAG-STAT6 with LANA-myc or vector alone were lysed in the absence or presence of different protease inhibitors as indicated, followed by immunoblotting against ...
Yuhong Li (448146), Chong Wang (120449), Shujun Gao (132959), Yin Tong (789660), Liming Zhang (213971), Jianqing Xu (135427), Erle S. Robertson (177370), Zhenghong Yuan (12153), Fang Wei (31236), Yanling Feng (294987), Bin Wang (30851), Caixia Zhu (344874), Qiliang Cai (180057)   +12 more
core   +1 more source

Age‐Associated B Cells Contribute to Inflammation Via Antibody‐Independent Mechanisms in Takayasu Arteritis

Arthritis &Rheumatology, EarlyView.
Objective Although Takayasu arteritis (TAK) is not a prototypical autoantibody‐mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B cell activation and its contributions to TAK pathogenesis. Methods Histologic analysis of paravascular lymph nodes and affected arteries was conducted
Chenglong Fang, Xiaoxi Yang, Xiaochuan Sun, Shangyi Jin, Lihong Du, Jinwei Gao, Jing Li, Zhen Chen, Yuexin Chen, Mengtao Li, Xinping Tian   +10 more
wiley   +1 more source

STAT6 blockade ameliorates thyroid function in Graves’ disease via downregulation of the sodium/iodide symporter

Endocrine Connections
Background: Signal transducer and activator of transcription 6 (STAT6) is an important nuclear transcription factor. Previous studies demonstrated that blocking STAT6 can ameliorate thyroid function by reducing serum T3 and T4.
Qian Yang, Qinnan Zhang, Fanfan Pan, Bingbing Zha   +3 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source