Results 61 to 70 of about 30,689 (278)

INTERACTION OF TRANSCRIPTION FACTORS PAX-5 AND STAT6 IN PATHOGENESIS OF ALLERGIC BRONCHIAL ASTHMA

Медицинская иммунология, 2014
The aim of this work was to study an opportunity of coordinated expression of PAX-5 and STAT6 in bronchial asthma (BA) development. 35 healthy controls, 83 patients with allergic bronchial asthma (ABA) and 63 patients with nonallergic bronchial asthma ...
V. N. Mineev, L. N. Sorokina, M. A. Nyoma, A. V. Eremeeva   +3 more
doaj   +1 more source

RTA interacts with STAT6.

, 2018
(A) Ectopic expression of exogenous STAT6 interacted with RTA. Whole cell lysate (WCL) from 293T cells co-transfected with different combination of FLAG-STAT6 and RTA-myc as indicated, were subjected to immunoprecipitation (IP) followed by immunoblotting
Ling Ding (302098), Chong Wang (120449), Qing Zhu (349093), Cankun Cai (6065465), Feng Gu (45619), Wenjia Xu (815857), Yuyan Wang (283747), Zhikang Qian (251624), Zhenghong Yuan (12153), Fang Wei (31236), Erle Robertson (209092), Caixia Zhu (344874), Qiliang Cai (180057)   +12 more
core   +1 more source

Disruption of STAT6 Signal Promotes Cardiac Fibrosis Through the Mobilization and Transformation of CD11b+ Immature Myeloid Cells

Frontiers in Physiology, 2020
Cardiac fibrosis is an important pathological basis of various cardiovascular diseases. The roles of STAT6 signal in allergy, immune regulation, tumorigenesis, and renal fibrosis have been documented.
Weiwei Zhang, Baoling Zhu, Baoling Zhu, Suling Ding, Xiangfei Wang, Xiangfei Wang, Jian Wu, Jian Wu, Xiaowei Zhu, Xiaowei Zhu, Yunzeng Zou, Yunzeng Zou, Junbo Ge, Junbo Ge, Minghong Tong, Xiangdong Yang, Xiangdong Yang   +16 more
doaj   +1 more source

STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid Nephropathy

Cells, 2021
Renal fibrosis is a pathologic feature of chronic kidney disease, which can lead to end-stage kidney disease. Myeloid fibroblasts play a central role in the pathogenesis of renal fibrosis.
Baihai Jiao, Changlong An, Hao Du, Melanie Tran, Penghua Wang, Dong Zhou, Yanlin Wang   +6 more
doaj   +1 more source

STAT6 is associated with LANA.

, 2017
(A) Endogenous STAT6 interacts with LANA in PEL cells. Whole cell lysates (WCL) from PEL cells (BC3, BCBL1) and B lymphoma cells (DG75) were individually subjected to immunoprecipitation (IP) and immunoblotting (IB) assay as indicated.
Yuhong Li (448146), Chong Wang (120449), Shujun Gao (132959), Yin Tong (789660), Liming Zhang (213971), Jianqing Xu (135427), Erle S. Robertson (177370), Zhenghong Yuan (12153), Fang Wei (31236), Yanling Feng (294987), Bin Wang (30851), Caixia Zhu (344874), Qiliang Cai (180057)   +12 more
core   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells.

PLoS ONE, 2020
Approximately 20% of breast cancers are HER2-positive. Trastuzumab has improved patient outcomes significantly for these cancers. However, acquired resistance remains a major hurdle in the clinical management of these patients.
Molly DiScala, Matthew S Najor, Timothy Yung, Deri Morgan, Abde M Abukhdeir, Melody A Cobleigh   +5 more
doaj   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR- expression and activation in macrophages

, 2020
The signal transducer and activator of transcription 6 (STAT6) transcription factor activates peroxisome proliferator-activated receptor gamma (PPAR-)-regulated gene expression in immune cells.
김민석, 이지희, 최지하, 김희선   +3 more
core   +2 more sources

Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus

, 2001
We inoculated BALB/c mice deficient in STAT6 (STAT6-/-) and their wild-type (wt) littermates (STAT6+/+) with the natural mouse pathogen, ectromelia virus (EV).
Mahalingam, Surendran, Kiyoshi Takeda, Shizuo Akira, Karupiah, Gunasegaran, Foster, Paul S, Paul S. Foster, Matthaei, Klaus, Surendran Mahalingam, Klaus I. Matthaei, Takeda, Kiyoshi, Akira, Shizuo, Gunasegaran Karupiah   +11 more
core   +1 more source