Results 61 to 70 of about 29,695 (266)
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Nucleocytoplasmic Transport of the Transcription Factor STAT6 [PDF]
, 2010 Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors that regulate cytokine signaling pathways.
Chen, Hui-Chen
core +1 more source
STAT6-Dependent Regulation of Th9 Development [PDF]
The Journal of Immunology, 2012 Abstract Th cell effector subsets develop in response to specific cytokine environments. The development of a particular cytokine-secreting pattern requires an integration of signals that may promote the development of opposing pathways.
Ritobrata, Goswami +6 more
openaire +2 more sources
Advanced Science, EarlyView.Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie +10 more
wiley +1 more source
Drug Design, Development and Therapy, 2020 Shuo Zhang,1,2 Wen-chong Sun,2 Zuo-di Liang,2 Xiu-ru Yin,2 Zhen-rong Ji,2 Xiao-huan Chen,2 Min-jie Wei,1 Ling Pei2 1Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110001, People’s Republic of China ...
Zhang S +7 more
doaj
Cells, 2021 Renal fibrosis is a pathologic feature of chronic kidney disease, which can lead to end-stage kidney disease. Myeloid fibroblasts play a central role in the pathogenesis of renal fibrosis.
Baihai Jiao +6 more
doaj +1 more source
STAT6 is associated with LANA.
, 2017 (A) Endogenous STAT6 interacts with LANA in PEL cells. Whole cell lysates (WCL) from PEL cells (BC3, BCBL1) and B lymphoma cells (DG75) were individually subjected to immunoprecipitation (IP) and immunoblotting (IB) assay as indicated.
Yuhong Li (448146) +12 more
core +1 more source
Advanced Science, EarlyView.A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao +7 more
wiley +1 more source
Advanced Science, EarlyView.eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin +3 more
wiley +1 more source
INTERACTION OF TRANSCRIPTION FACTORS PAX-5 AND STAT6 IN PATHOGENESIS OF ALLERGIC BRONCHIAL ASTHMA
Медицинская иммунология, 2014 The aim of this work was to study an opportunity of coordinated expression of PAX-5 and STAT6 in bronchial asthma (BA) development. 35 healthy controls, 83 patients with allergic bronchial asthma (ABA) and 63 patients with nonallergic bronchial asthma ...
V. N. Mineev +3 more
doaj +1 more source