Results 101 to 110 of about 29,695 (266)
Specific inhibition of Src-Tyrosine kinase reduces STAT6 activation.
, 2012 (A) Tip, Lck and STAT6 transfected 293T cells were treated with PP2 or the non-active control substance PP3 (10 µM in DMSO each). STAT6, pSTAT6, Tip and GAPDH were detected by fluorescent immunoblotting on the same membrane.
Armin Ensser (173680) +7 more
core +1 more source
Phytotherapy Research, EarlyView.Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei +4 more
wiley +1 more source
Allergy, EarlyView.IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.
Giorgia Moschetti +18 more
wiley +1 more source
Allergy, EarlyView.Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri +11 more
wiley +1 more source
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
Nature Communications, 2019 Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.
Tao Yu +22 more
doaj +1 more source
Stat6 dependent goblet cell hyperplasia during intestinal nematode infection
, 2015 To identify the role of signal transducer and activator of transcription factor 6 (Stat6) in the development of intestinal goblet cell hyperplasia during nematode infection, we compared the number of goblet cells in Stat6 deficient (Stat6 -/-) mice with ...
Ma, C +4 more
core +1 more source
Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases
Allergy, EarlyView.ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz +22 more
wiley +1 more source
Regulation des STAT6/ Koaktivator Komplexes in der Zytokin induzierten Transkription [PDF]
, 2010 STAT-Proteine sind latente Transkriptionsfaktoren mit essentiellen Funktionen, die durch spezifische Stimuli aktiviert werden. STAT6 ist wesentlich an der humoralen Immunantwort durch Weiterleitung extrazellulärer Signale in Form von IL-4 und IL-13 ...
Münz, Tobias
core
PLAG inhibits IL-4 induced STAT6 phosphorylation.
, 2016 (A) Various concentration of a STAT6 inhibitor (STAT6i, AS1517499) were treated onto A549 cells which were activated by IL-4 (10 ng/mL), and showed inhibitory effect on the secretion of CCL26 from the epithelial cells in a concentration-dependent manner.
Young-Jun Kim (696507) +9 more
core +1 more source
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source