Results 121 to 130 of about 29,695 (266)

STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis

Advanced Science
Pulmonary fibrosis (PF) remains a clinically intractable condition with limited therapies. Ferroptosis has emerged as a critical driver of PF. The previous study demonstrates that increased secretion of tissue plasminogen activator from ferroptotic ...
Youjing Yang, Guangbin Huang, Tao Zhang, Yi Ling, Junyu Jiang, Dingyuan Du, Yu Ma, Shasha Tao   +7 more
doaj   +1 more source

Proteolytic Processing of Stat6 Signaling in Mast Cells as a Negative Regulatory Mechanism

, 2002
Accumulating evidence has shown the importance of Stat6-mediated signaling in allergic diseases. In this study, we show a novel regulatory mechanism of Stat6-mediated signaling in mast cells. When Stat6 is activated by interleukin (IL)-4 and translocated
Kotaro Suzuki, Kiyoshi Takeda, Shizuo Akira, Shin-ichiro Kagami, Hiroshi Nakajima, Koichi Hirose, Takaki Hiwasa, Yasushi Saito, Kei Ikeda, Akira Suto, Itsuo Iwamoto   +10 more
core   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

STAT6 associated with mitochondria in MEFs derived from wildtype (wt) or STAT6^SH2-/SH2- mice.

, 2013
Panel A. MEFs derived from wt and STAT6SH2-/SH2- grown in 35–mm plates were washed using the digitonin-sucrose buffer and then immunostained for STAT6 and F1-ATPase. The cells were imaged using a 100x oil immersion objective.
Feng-Xia Liang (286419), Rasel Khan (286413), Yang-Ming Yang (286417), Pravin B. Sehgal (286421), Jason E. Lee (286415)   +4 more
core   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

STAT6、HMGA2在前列腺癌中的表达及与患者临床病理特征的相关性研究

Zhongguo shiyan zhenduanxue, 2023
目的 分析转录激活因子6(STAT6)、高迁移率蛋白A2(HMGA2)在前列腺癌中的表达及与患者临床病理特征的相关性。方法 选择2016年7月到2019年7月商丘市第一人民医院行手术切除的前列腺癌患者60例，留取前列腺癌组织和距离癌组织边缘2 cm以上癌旁组织。免疫组化法检测前列腺癌组织、癌旁组织标本STAT6、HMGA2表达。分析STAT6、HMGA2与前列腺癌患者临床病理特征的关系。结果 前列腺癌组织中STAT6、HMGA2阳性率较高，STAT6、HMGA2阳性表达率与Gleason评分、临床分期 ...
张玉文, 梁运霞, 李晓丽
doaj  

STAT6 Immunohistochemistry: A Biomarker for Eosinophilic Esophagitis

Archives of Pathology & Laboratory Medicine
Context.— Eosinophilic esophagitis (EoE) is a chronic, immune-mediated condition with overlapping histologic features with gastroesophageal reflux disease and other esophagitis subtypes. Current diagnostic criteria based on eosinophil density and basal zone hyperplasia lack specificity, necessitating more ...
Chen, Mayer, Osher, Dahan, Asaf, Levartovsky, Iris, Barshack, Adam, Goldman, Michael, Schvimer   +5 more
openaire   +2 more sources

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science
In both acute and chronic pancreatitis, the local pancreatic immune response has a significant influence on the course of the disease. Utilizing a murine model deficient in STAT6, we demonstrate that the IL‐4/IL‐13/STAT6‐signaling pathway, which is a ...
Hager ElSheikh, Annika Salvers, Judith Piesker, Shenja Buchholz, Rabea Lange, Sabine Ameling, Leif Steil, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Frank U. Weiss, Matthias Sendler, Juliane Glaubitz   +13 more
doaj   +1 more source