Results 121 to 130 of about 30,689 (278)
Advanced SciencePulmonary fibrosis (PF) remains a clinically intractable condition with limited therapies. Ferroptosis has emerged as a critical driver of PF. The previous study demonstrates that increased secretion of tissue plasminogen activator from ferroptotic ...
Youjing Yang +7 more
doaj +1 more source
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source
Proteolytic Processing of Stat6 Signaling in Mast Cells as a Negative Regulatory Mechanism
, 2002 Accumulating evidence has shown the importance of Stat6-mediated signaling in allergic diseases. In this study, we show a novel regulatory mechanism of Stat6-mediated signaling in mast cells. When Stat6 is activated by interleukin (IL)-4 and translocated
Kotaro Suzuki +10 more
core +1 more source
Adenosine—A Regulator of Human Testicular Peritubular Cells
Andrology, EarlyView.ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz +12 more
wiley +1 more source
Parasite-induced arg1 expression in macrophages is dependent on STAT6.
, 2014 Expression of A) STAT6 mRNA and B) arg1 mRNA in BMDMs that were uninfected (Un) or infected in vitro with L. donovani (Inf) for 24 h after transfection with STAT6-specific knockdown siRNA (STAT6 KD) or scrambled siRNA (Control). Shown is the mean and SEM
Peter C. Melby (187396) +5 more
core +1 more source
British Journal of Haematology, EarlyView.Summary Comprehensive genome and transcriptome profiling can inform the diagnosis, prognosis and management of relapsed/refractory (R/R) solid malignancies, yet its integration into clinical care has lagged despite strong biological rationale. We evaluated the clinical utility of whole genome and transcriptome analysis (WGTA) in 65 patients (37 ...
Kathleen Wee +24 more
wiley +1 more source
PLAG inhibits IL-4 induced STAT6 phosphorylation.
, 2016 (A) Various concentration of a STAT6 inhibitor (STAT6i, AS1517499) were treated onto A549 cells which were activated by IL-4 (10 ng/mL), and showed inhibitory effect on the secretion of CCL26 from the epithelial cells in a concentration-dependent manner.
Young-Jun Kim (696507) +9 more
core +1 more source
STAT6、HMGA2在前列腺癌中的表达及与患者临床病理特征的相关性研究
Zhongguo shiyan zhenduanxue, 2023 目的 分析转录激活因子6(STAT6)、高迁移率蛋白A2(HMGA2)在前列腺癌中的表达及与患者临床病理特征的相关性。方法 选择2016年7月到2019年7月商丘市第一人民医院行手术切除的前列腺癌患者60例，留取前列腺癌组织和距离癌组织边缘2 cm以上癌旁组织。免疫组化法检测前列腺癌组织、癌旁组织标本STAT6、HMGA2表达。分析STAT6、HMGA2与前列腺癌患者临床病理特征的关系。结果 前列腺癌组织中STAT6、HMGA2阳性率较高，STAT6、HMGA2阳性表达率与Gleason评分、临床分期 ...
张玉文, 梁运霞, 李晓丽
doaj
Type I IFN induced IL1-Ra expression in hepatocytes is mediated by activating STAT6 through the formation of STAT2 : STAT6 heterodimer [PDF]
, 2010 [[abstract]]The biological activities of type I interferons (IFNs) are mediated by their binding to a heterodimer receptor complex (IFNAR1 and IFNAR2), resulting in the activation of the JAK (JAK1 and TYK2)-STAT (1, 2, 3, 5 isotypes) signalling pathway ...
Wan, L (Wan, Lei); Lin, CW (Lin, Cheng-Wen); Lin, YJ (Lin, Ying-Ju); Sheu, JJC (Sheu, Jim J. C.); Chen, BH (Chen, Bing-Hung); Liao, CC (Liao, Chiu-Chu); Tsai, Y (Tsai, Yuhsin); Lin, WY (Lin, Wei-Yong); Lai, CH (Lai, Chih-Ho); Tsai, FJ (Tsai, Fuu Jen)
core
British Journal of Pharmacology, EarlyView.Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka +3 more
wiley +1 more source