Results 131 to 140 of about 30,689 (278)

STAT6 Immunohistochemistry: A Biomarker for Eosinophilic Esophagitis

Archives of Pathology & Laboratory Medicine
Context.— Eosinophilic esophagitis (EoE) is a chronic, immune-mediated condition with overlapping histologic features with gastroesophageal reflux disease and other esophagitis subtypes. Current diagnostic criteria based on eosinophil density and basal zone hyperplasia lack specificity, necessitating more ...
Chen, Mayer, Osher, Dahan, Asaf, Levartovsky, Iris, Barshack, Adam, Goldman, Michael, Schvimer   +5 more
openaire   +2 more sources

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science
In both acute and chronic pancreatitis, the local pancreatic immune response has a significant influence on the course of the disease. Utilizing a murine model deficient in STAT6, we demonstrate that the IL‐4/IL‐13/STAT6‐signaling pathway, which is a ...
Hager ElSheikh, Annika Salvers, Judith Piesker, Shenja Buchholz, Rabea Lange, Sabine Ameling, Leif Steil, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Frank U. Weiss, Matthias Sendler, Juliane Glaubitz   +13 more
doaj   +1 more source

KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity

Brain Research Bulletin
In ischemic stroke (IS), microglia exhibit dynamic functional shifts, contributing to tissue damage during the acute phase and promoting repair in the chronic phase. The mechanisms underlying these transitions are poorly understood.
Yixin Li, Li Peng, Yang Zhou, Yan You, Jin Jiang, Yong Luo   +5 more
doaj   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

, 2011
SummarySTAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection.
Jun Gu, Zhengfan Jiang, Xiang Zhou, Wenxiang Sun, Delia Gutman, Hui Sun, Weiwei Xia, Huihui Chen, Lu Chen, Jing Yang, Hiroki Ishikawa, Yukun Guan, Glen Barber, Yutao Wang, Zhihai Qin, Hong Tang, Fuping You, Jiang, Zhengfan, Qin, Zhihai, You, Fuping, Yang, Jing, Gu, Jun, Sun, Hui, Sun, Wenxiang, Chen, Huihui, Guan, Yukun, Xia, Weiwei, Barber, Glen, Tang, Hong, Wang, Yutao, Zhou, Xiang, Ishikawa, Hiroki, Chen, Lu, Gutman, Delia   +33 more
core   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Oligonucleotide fishing for STAT6: cross-talk between IL-4 and chemokines.

, 2001
Udgivelsesdato: 2001-nullSignal transducer and activator of transcription 6 (STAT6) is essential for the biological activities of interleukin-4 (IL-4) and the development of allergic responses in mice. Here we report on a sensitive and specific assay for
Eriksen, K W, Nielsen, M, Nissen, Mogens Holst, Röpke, C, Kaltoft, K, Svejgaard, A, Ødum, N   +6 more
core   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

Characterization of the specificityof the anti-STAT6 immunofluoresence and its organellar localization by immunogold electron microscopy.

, 2013
Panel A. Anti-STAT6 immunofluoresence assayed using the rabbit pAb colocalizing with F1-ATPase in the cytoplasm of digitonin-washed Hep3B cells was compared to that of an irrelevant pAb (G6PD). Scale bar = 10 µm. Panel B.
Feng-Xia Liang (286419), Rasel Khan (286413), Yang-Ming Yang (286417), Pravin B. Sehgal (286421), Jason E. Lee (286415)   +4 more
core   +1 more source

MD‐1 Deficiency Mitigates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation via cGAS‐STING Dependent Pathway in Macrophages

Cell Proliferation, EarlyView.
MD‐1 is induced and activated in macrophages. The activated MD‐1 subsequently promotes the cGAS‐STING‐TBK1‐IRF3 signalling pathway to activate the NLRP3 inflammasome, and subsequently increases pro‐inflammatory macrophage polarisation and decreases plaque stability to accelerate the development of atherosclerosis.
Fang Zhao, Zhili Jin, Zhiwei Cai, Quan Zhang, Tao He, Xiangjie Kong, Ming Chen, Zhibing Lu, Xiaorong Hu, Wen‐Lin Cheng   +9 more
wiley   +1 more source