Results 111 to 120 of about 29,695 (266)

Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells

Acta Neuropathologica Communications, 2019
Multifunctional signal transducer and activator of transcription (STAT) proteins play important roles in cancer. Here, we have shown that STAT6 is epigenetically silenced in some cases of malignant glioblastoma, which facilitates cancer cell survival in ...
Soo Jung Park, Hyunmi Kim, Se Hyuk Kim, Eun-hye Joe, Ilo Jou   +4 more
doaj   +1 more source

LANA enhances the affinity of STAT6 bound to RTA promoter.

, 2017
(A) Intact or cleaved form of STAT6 bound to RTA promoter and enhanced by LANA. HEK293 cells co-transfected with the indicated plasmids, were subjected to Chromatin immunoprecipitation (ChIP) with exogenous STAT6 (full length, Y641F, ΔTAD, ΔDBD, and ΔN).
Yuhong Li (448146), Chong Wang (120449), Shujun Gao (132959), Yin Tong (789660), Liming Zhang (213971), Jianqing Xu (135427), Erle S. Robertson (177370), Zhenghong Yuan (12153), Fang Wei (31236), Yanling Feng (294987), Bin Wang (30851), Caixia Zhu (344874), Qiliang Cai (180057)   +12 more
core   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus.

PLoS Pathogens, 2018
Aberrations in STAT6-mediated signaling are linked to the development of multiple cancer types. Increasing evidence has shown that activation of human oncogenic herpesvirus lytic replication is crucial for viral tumorigenesis.
Feng Gu, Chong Wang, Fang Wei, Yuyan Wang, Qing Zhu, Ling Ding, Wenjia Xu, Caixia Zhu, Cankun Cai, Zhikang Qian, Zhenghong Yuan, Erle Robertson, Qiliang Cai   +12 more
doaj   +1 more source

LANA enhances the inhibitory function of STAT6 on transcription of RTA through STAT6-binding sites within RTA promoter.

, 2017
(A) Schematic of putative STAT6-binding sites within RTA and LANA promoters. The RTA (or LANA) promoter-driven luciferase reporters RTAp-Luc (or LANAp-Luc) are shown at the bottom panel.
Yuhong Li (448146), Chong Wang (120449), Shujun Gao (132959), Yin Tong (789660), Liming Zhang (213971), Jianqing Xu (135427), Erle S. Robertson (177370), Zhenghong Yuan (12153), Fang Wei (31236), Yanling Feng (294987), Bin Wang (30851), Caixia Zhu (344874), Qiliang Cai (180057)   +12 more
core   +1 more source

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity [PDF]

, 2011
SummarySTAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection.
Chen, Huihui, Jun Gu, Zhengfan Jiang, Zhou, Xiang, Jiang, Zhengfan, Xiang Zhou, Guan, Yukun, Wenxiang Sun, Delia Gutman, Sun, Wenxiang, Ishikawa, Hiroki, Sun, Hui, Hui Sun, Weiwei Xia, Huihui Chen, Gu, Jun, You, Fuping, Qin, Zhihai, Lu Chen, Jing Yang, Hiroki Ishikawa, Gutman, Delia, Barber, Glen, Yukun Guan, Glen Barber, Yutao Wang, Zhihai Qin, Wang, Yutao, Xia, Weiwei, Chen, Lu, Yang, Jing, Hong Tang, Tang, Hong, Fuping You   +33 more
core   +1 more source

SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistance

Cell Death and Disease
Hepatocellular carcinoma (HCC) is a major global health burden. Despite recent advances in immunotherapy, tyrosine kinase inhibitors (TKIs) treatment or combined therapies, therapeutic resistance and disease progression remain significant challenges ...
Chia-Lung Tsai, Ming-Chin Yu, Cheng-Lung Hsu, Hsiang-Yu Tang, Yun-Shien Lee, Lang-Ming Chi, Sey-En Lin, Mei-Ling Cheng, Heng-Yuan Hsu, Chi-Neu Tsai   +9 more
doaj   +1 more source

Expression of Stat6 and pStat6 in the spleen.

, 2014
A-D, Spleen sections from 8-week-old normal (left) and Ttc7fsn (right) mice stained with anti-Stat6 or anti-pStat6 (green), anti-CD4 (blue), and anti-IgM (red). Yellow indicates co-localization of B cells with Stat6.
Beth L. Hill (380277), Stephen Pelsue (100584)   +1 more
core   +1 more source

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source