Results 141 to 150 of about 29,695 (266)

A 3‐year‐old girl with a left optic nerve tumor

Brain Pathology, EarlyView.
Samuel López Muñoz, Alberto Berjón, Carlos Rodríguez Antolín, Claudia Sánchez Lara, Marta Mendiola, Victoria Heredia Soto, Álvaro Lassaletta, Carlos González Pérez, Pedro Rubio Aparicio, Jorge Zamorano, Isabel Esteban Rodríguez   +10 more
wiley   +1 more source

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source

A Mouse Model of Airway Disease: Oncostatin M-Induced Pulmonary Eosinophilia, Goblet Cell Hyperplasia, and Airway Hyperresponsiveness Are STAT6 Dependent, and Interstitial Pulmonary Fibrosis Is STAT6 Independent

, 2011
Oncostatin M (OSM), a pleiotropic cytokine of the gp130 cytokine family, has been implicated in chronic allergic inflammatory and fibrotic disease states associated with tissue eosinophilia.
Ramzi Fattouh, Waliul I. Khan, Manel Jordana, Alba Llop-Guevara, Dominik K. Fritz, Christine Kerr, Carl D. Richards   +6 more
core   +1 more source

Emerging Roles of PSTPIP2 in Autoimmunity: From Mechanism to Therapeutic Implications

Immunology, EarlyView.
PSTPIP2 acts as a key brake on myeloid inflammation by suppressing IL‐1β‐driven signalling, macrophage dysregulation and inflammation‐associated bone remodelling. Its emerging roles in CRMO/CMO, rheumatoid arthritis, SAPHO syndrome and bullous pemphigoid support its potential as a biomarker and therapeutic target.
Erdong Zhang, Fengyu Liu, Yongle Wei, Guoqiang Li, Liujie Zheng, Lin Jin, Feng Luan, Yingze Zhang, Ling Wang, Zhiyong Hou   +9 more
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

LANA promotes nuclear localization of STAT6 independent of Y641-phosphorylation.

, 2017
(A) Inhibition of LANA blocks nuclear localization of STAT6. Confocal microscopy of endogenous STAT6 (red) and merged in PEL cells BC3 with lentivirus-mediated constitutively knocked down of LANA (shLANA) or luciferase control (shCtrl).
Yuhong Li (448146), Chong Wang (120449), Shujun Gao (132959), Yin Tong (789660), Liming Zhang (213971), Jianqing Xu (135427), Erle S. Robertson (177370), Zhenghong Yuan (12153), Fang Wei (31236), Yanling Feng (294987), Bin Wang (30851), Caixia Zhu (344874), Qiliang Cai (180057)   +12 more
core   +1 more source

Persisting Region‐Specific Microglia Activation and Synaptic Imbalance During Remission in a DSS‐Induced Colitis Model

Glia, Volume 74, Issue 11, November 2026.
Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton, Luis E. Villafuerte, Alejandra P. Garza, Nina Lindemann, Elisa Wider‐Eberspächer, Dunja Bruder, Ildiko R. Dunay   +6 more
wiley   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Turning Off STAT6 with a Targeted Degrader

Journal of Medicinal Chemistry
While an attractive target for treating a range of human diseases and conditions, signal transducer and activator of transcription 6 (STAT6) has resisted drug discovery efforts for decades. This Viewpoint summarizes the discovery of a highly potent, selective STAT6 degrader with minimal off-target activity.
openaire   +3 more sources

Bovine milk regulates collagen synthesis via STAT6.

, 2015
(a) Human skin fibroblasts were treated with 1, 5, 10 and 20% bovine milk with or without 200 μM leflunomide, an inhibitor of p-STAT6. After 0,5, 2 and 6h cell lysates were examined for p-STAT6 induction by Western blot. (b) Cells were treated with 1, 5,
Johannes Kleemann (764576), Roland Kaufmann (481793), Jutta Müller (764577), Nadja Zöller (764575), Stefan Kippenberger (481792), Eva Valesky (764578), Matthias Hofmann (481794), August Bernd (481795), Markus Meissner (244917)   +8 more
core   +1 more source