Results 161 to 170 of about 30,689 (278)
Nucleocytoplasmic Transport of the Transcription Factor STAT6
Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors that regulate cytokine signaling pathways.
Chen, Hui-Chen
core
Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers
ChemMedChem, Volume 21, Issue 20, 28 October 2026.Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, Volume 20, Issue 10, Page 2449-2465, October 2026.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Interleukin-4 Supplementation During In Vitro Culture Modulates the Expression of Stress- and Immune-Related Genes During Porcine Blastocyst Development. [PDF]
Reprod Domest AnimABSTRACT The aim of this study was to evaluate the effect of supplementing in vitro culture medium of porcine zygotes with interleukin‐4 (IL‐4) on their developmental competence and quality. Cumulus‐oocyte complexes (COCs) were matured and fertilized in vitro.
Garcia-Canovas M +7 more
europepmc +2 more sources
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Function-based OBOC screening for the direct discovery of potent protein-protein interaction inhibitors. [PDF]
RSC Chem BiolWang HM +8 more
europepmc +1 more source
AND Gates as Sources of Biological Nonlinearity: Relevance to Genetic Dominance
Advanced Biology, Volume 10, Issue 10, October 2026.Biological switches often demand that several molecular conditions hold simultaneously. The authors show that such AND‐gating generates S‐shaped responses even when every underlying step is gradual and non‐cooperative. Near the transition, halving a regulator abundance produces a far greater drop in output, offering a simple explanation for dominance ...
Anis Toussirt, Reiner A. Veitia
wiley +1 more source
Esophageal pendulum: a rare case report of a giant solitary fibrous tumor of the esophagus. [PDF]
J Surg Case RepKhan MA, Anees A, Ahmed M, Jameel H.
europepmc +1 more source
Advanced Science, Volume 13, Issue 60, 28 October 2026.Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie +10 more
wiley +1 more source