Synergistic interaction between the macrophage polarizing signals IL-4 and IFNγ is controlled by the STAT6/STAT1/IRF1 axis. [PDF]
Varga Z +21 more
europepmc +1 more source
Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait +5 more
wiley +1 more source
Glioma-associated oncogene homolog 1-altered mesenchymal tumour of the upper oesophageal sphincter. [PDF]
Hebert S +3 more
europepmc +1 more source
Ferroptosis: Newly Emerged Regulator for Human Disease
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao +4 more
wiley +1 more source
The Health Benefits of Exercise: Molecular and Cellular Mechanisms
Our synthesis integrates evidence on exercise‐induced regulatory mechanisms across multiple systems (musculoskeletal, cardiovascular, nervous, metabolic and immune), cross‐system, and aging. We also discusses adaptive regulation of exercise in extreme environments, along with the prospects and challenges of multiomics and AI‐driven precision exercise ...
Peifeng Ying +12 more
wiley +1 more source
Solitary fibrous tumor of the posterior fossa: a rare and atypical case report. [PDF]
Hermassi MA +5 more
europepmc +1 more source
Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao +10 more
wiley +1 more source
Construction and Characterization of Paired Patient-Derived Cell Models for Solitary Fibrous Tumors (SFTs). [PDF]
Vahdat Azad F +7 more
europepmc +1 more source
Tissue‐Resident Macrophage in Inflammation and Cancer
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang +13 more
wiley +1 more source
Clinical characteristics and management of renal solitary fibrous tumors: a narrative review with literature-derived case evidence. [PDF]
Zhao L +8 more
europepmc +1 more source

