Results 181 to 190 of about 30,689 (278)

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

PDLIM4 promotes dephosphorylation of STAT transcription factors by recruiting PTP-BL and inhibits Th1, Th2, and Th17 cell differentiation. [PDF]

Int Immunol
Jodo A, Nakahira M, Kochi Y, Sugimoto-Ishige A, Kaisho T, Tanaka T.   +5 more
europepmc   +1 more source

Exercise Modulates the Osteoimmune Axis: Myokine‐Mediated Mechanisms in Diabetic Bone Disease

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 7, October 2026.
Exercise activates skeletal muscle to release myokines (irisin, acute IL‐6, IL‐15 and BAIBA) and suppress myostatin, which may help counteract T2DM‐induced hyperglycemia, AGE accumulation, chronic inflammation and osteoimmune imbalance, potentially contributing to improved bone quality and reduced fracture risk.
Chao Wu, Jun Zou, Yu Yuan
wiley   +1 more source

Protein phosphates 2A (PP2A) regulates IL-4- mediated STAT6 signalling

, 2003
Protein phosphates 2A (PP2A) regulates IL-4- mediated STAT6 ...
Bendtzen, K., Geisler, C., Nielsen, M., Leick, V., Andersen, Anders Woetmann, Rieneck, K., Brockdorff, J., Ødum, Niels   +7 more
core  

Generating and Expanding Conventional Type 1 Dendritic Cells

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Conventional type 1 dendritic cells (cDC1s) are difficult to obtain in sufficient numbers. This Review compares strategies based on progenitor differentiation, cell programming, or expansion in tissues, and shows how differences in cell identity, population composition, function, and yield should guide platform selection.
Sukriti Sharma, Shandré Pillay, Christian T. Mayer   +2 more
wiley   +1 more source

Synergistic interaction between the macrophage polarizing signals IL-4 and IFNγ is controlled by the STAT6/STAT1/IRF1 axis. [PDF]

Nucleic Acids Res
Varga Z, Poscher A, Váradi EA, Cinege G, Izsán A, Erdős E, Benyhe-Kis B, Tihanyi AZ, Tzerpos P, Bene K, Halász L, Gémes N, Neuperger P, Tóth M, Migh E, Póliska S, Szebeni GJ, Walter JE, Dániel B, Csörgő B, Nagy L, Czimmerer Z.   +21 more
europepmc   +1 more source

Panax notoginseng Saponins Accelerate Diabetic Wound Repair by Minimizing Mitochondrial Dysfunction and Inhibiting Pyroptosis of Macrophage via Regulating Ephx2/11,12‐EET Axis

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Panax notoginseng saponins (PNS) accelerate diabetic wound healing via targeting the Ephx2/11,12‐EET axis in macrophages. PNS inhibits Ephx2 expression to elevate 11,12‐EET levels, which restores mitochondrial homeostasis by regulating mitochondrial dynamic proteins, reduces mtROS production, and subsequently suppresses NLRP3 inflammasome‐mediated ...
Nan Chen, Bo Zhu, Cai‐hua Sun, Tong Hou   +3 more
wiley   +1 more source

Case Report: Solitary fibrous tumor (SFT) of cerebellum: report of 2 cases. [PDF]

Front Surg
Guo G, Ma Z, Zhao L, Gao T, Sun Y, Liu Z, Liu Y, Li C.   +7 more
europepmc   +1 more source

Melanoma of the Scalp Harboring a Novel AGFG1::ERBB4 Fusion: A Case Report With Clinicopathologic and Genomic Characterization

Genes, Chromosomes and Cancer, Volume 65, Issue 10, October 2026.
ABSTRACT ERBB4 (HER4) gain‐of‐function missense mutations have been implicated in cutaneous melanoma. In contrast, structural rearrangements involving ERBB4 are exceedingly rare. We describe a 59‐year‐old man with a rapidly enlarging 4.2‐cm melanoma of the scalp with high‐risk pathologic features, including epithelioid to plasmacytoid cytomorphology ...
Xu Cao, Hong Yu, Kenneth L. Muldrew, Rachael M. Johnson, Li Liang, Ying Pei, Yve T. Huttenbach, C. Cameron Yin, Songlin Zhang   +8 more
wiley   +1 more source

STAT6 wt Allele [PDF]

, 2020
openaire   +1 more source