Results 11 to 20 of about 5,584 (128)

Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring. [PDF]

J Neurochem
Maternal obesity during pregnancy induces metabolic and inflammatory disturbances that alter the offspring brain environment, characterized by neuroinflammation, glial activation, disrupted neurotransmitter signaling, and mitochondrial and synaptic dysfunction, ultimately increasing the risk of adverse neurodevelopmental outcomes, with persistent ...
Schmitt LO, Faraco G, Stivanin TS, Gaspar JM.   +3 more
europepmc   +2 more sources

Uncovering the role of genetic polymorphisms in cervical insufficiency. [PDF]

Int J Gynaecol Obstet
Pathways and genes implicated in CI pathogenesis. Abstract Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks.
Kalinderi K, Kalinderis M, Chatzidimitriou M, Fidani L.   +3 more
europepmc   +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

Cancer stem cells in brain tumors: From origin to clinical implications

MedComm, Volume 4, Issue 4, August 2023., 2023
During tumorigenesis, the stemness of brain cancer stem cells is determined by diverse intrinsic and extrinsic forces that function simultaneously or independently over time. Intrinsic regulators include epigenetic regulators, transcription regulators, kinases, secretory molecules, metabolism regulators, other regulators and signaling pathways, while ...
Shuyun Lin, Kaishu Li, Ling Qi
wiley   +1 more source

Biomarkers in Schizophrenia: Current Approaches and New Developments-A Literature Review. [PDF]

Behav Neurol
Schizophrenia (SZ) is categorized as a chronic severe highly heritable brain disease. Symptoms include positive, negative, and cognitive symptoms. Despite numerous theories concerning the etiopathogenesis of SZ, the symptoms, although characteristic in their phenomenology, manifest themselves in a rather heterogeneous manner, which makes them subject ...
Sierakowska A, Niewiadomska E, Łabuda S, Bieniasiewicz A, Roszak M, Łabuz-Roszak B.   +5 more
europepmc   +2 more sources

The integrated stress response in lung disease. [PDF]

, 2014
Lungs are repeatedly exposed to inhaled toxic insults, such as smoke, diesel exhaust, and microbes, which elicit cellular stress responses. The phosphorylation of eukaryotic translation initiation factor 2α by one of four stress-sensing kinases triggers ...
Hiemstra, Pieter S, Marciniak, Stefan J, van 't Wout, Emily FA   +2 more
core   +1 more source

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation [PDF]

, 2016
yesInflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance.
Alomar, Anna D. White, Bain, Benoit Viollet, Benziane, Bess, Bijland, Boyle, Brenner, Castanares-Zapatero, Chen, Claire Rutherford, Cohen, Coughlan, Delyth Graham, Dong, Erik A. Richter, Ewart, Flannery, Foretz, Fritzen, Galic, García-García, Gauthier, Green, Guigas, Göransson, Habinowski, Hawley, Ian P. Salt, Jeong, Jørgensen, Kim, Kim, Kwon, Laderoute, Lee, Lihn, Lihn, Lumeng, Meares, Miyokawa-Gorin, Moreno, Mottillo, Nerstedt, Qu, Rhian M. Touyz, Rios, Ross, Rotter, Rutherford, Sag, Salt, Sarah J. Mancini, Scott, Shibata, Silvia Bijland, Sun, Takahashi, Thiefes, Timothy M. Palmer, Viollet, Wang, Wang, Wang, Woods, Wu, Xu, Yang, Zaha, Zhang, Zhao   +71 more
core   +5 more sources

IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13 [PDF]

, 2008
Background: IL-13 is a critical mediator of allergic asthma and associated airway hyperresponsiveness. IL-13 acts through a receptor complex comprised of IL-13Rα1 and IL-4Rα subunits with subsequent activation of signal transducer and activator of ...
M Humbert, T Naseer, DS Robinson, SP Hogan, G Grunig, L Cohn, L Cohn, Z Zhu, Q Chen, R Leigh, M Yoshida, GK Hershey, D Kuperman, A Tomkinson, T Akimoto, DA Kuperman, H Ogata, MM Mentink-Kane, SO Rahaman, MO Daines, S Fichtner-Feigl, SP Hogan, O Tliba, K Espinosa, DS Faffe, PE Moore, S Zuyderduyn, SA Shore, Q Peng, V Govindaraju, G Grynkiewicz, J Kellner, JC Laporte, SJ Hirst, S Yamamoto, HL Dickensheets, NM Heller, T Sato, Z Huang, H Huang, J Ohara, F Syed, T Zheng, S Yasunaga, MO Daines, JA Losman, D Hebenstreit, H Dickensheets   +47 more
core   +3 more sources

Silkworm expression system as a platform technology in life science [PDF]

, 2009
Many recombinant proteins have been successfully produced in silkworm larvae or pupae and used for academic and industrial purposes. Several recombinant proteins produced by silkworms have already been commercialized.
00397366, 2907, 2907, 2910, 2910, 4521, 4522, 4d68973e-f6ff-4d7d-9439-c121d8831040, 90238246, bd6a76a9-51e0-42ce-9e57-130004af2bc5, Kajikawa, Mizuho, Kato, Tatsuya, Maenaka, Katsumi, Park, Enoch Y.   +13 more
core   +2 more sources

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian, Ong, Wee Kiat, Pyne, Nigel J.   +2 more
core   +1 more source