Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity [PDF]
, 2016 Background: Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer's disease.
David J. Volsky +8 more
core +13 more sources
AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice. [PDF]
, 2011 International audienceABSTRACT: BACKGROUND: Acute ozone exposure causes lung oxidative stress and inflammation leading to lung injury. At least one mechanism underlying the lung toxicity of ozone involves excessive production of reactive oxygen and ...
Hulo, Sébastien +6 more
core +3 more sources
CLU "in and out": looking for a link [PDF]
, 2009 Cancer cells need to interact synergistically with their surrounding microenvironment to form a neoplasm and to progress further to colonize distant organs.
Mazzarelli, P +4 more
core +4 more sources
Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation [PDF]
, 2013 AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy balance. AMPK phosphorylates and regulates many proteins concerned with nutrient metabolism, largely acting to suppress anabolic ATP-consuming pathways while ...
Ahmadian +182 more
core +1 more source
The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes [PDF]
, 2014 Rationale: Chronic obstructive pulmonary disease (COPD) is a phenotypically heterogeneous disease. In COPD, the presence of emphysema is associated with increased mortality and risk of lung cancer.
Belloni, Paula +13 more
core +5 more sources
Gram-positive pathogenic bacteria induce a common early response in human monocytes [PDF]
, 2010 Background We infected freshly isolated human peripheral monocytes with live bacteria of three clinically important gram-positive bacterial species, Staphylococcus aureus, Streptococcus pneumoniae and Listeria monocytogenes and studied the ensuing early ...
Svetlin Tchatalbachev +3 more
core +2 more sources
Regulators of G protein signalling proteins in the human myometrium [PDF]
, 2009 The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Abramow-Newerly +52 more
core +1 more source
Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma [PDF]
, 2014 Glaucoma is a progressive optic neuropathy characterized by visual field defects that ultimately lead to irreversible blindness (Alward, 2000; Anderson et al., 2006).
Buys, Emmanuel S. +3 more
core +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients [PDF]
, 2010 Background TNFRSF11B computational development network construction and analysis of frontal cortex of HIV encephalitis (HIVE) is very useful to identify novel markers and potential targets for prognosis and therapy.
Ju X Huang, L Wang, Ming H Jiang
core +1 more source