Interleukin‐17 and its target genes: mechanisms of interleukin‐17 function in disease [PDF]
Immunology, 2010 SummaryInterleukin‐17 (IL‐17) has emerged as a central player in the mammalian immune system. Although this cytokine exerts a host‐defensive role in many infectious diseases, it promotes inflammatory pathology in autoimmunity and other settings. A myriad of studies have focused on how IL‐17‐producing cells are generated.
Reiko M, Onishi, Sarah L, Gaffen
openaire +2 more sources
Serum interleukin-17 (IL-17) in chronic periodontitis patients
Padjadjaran Journal of Dentistry, 2017 Introduction: Explorations into the periodontal medicine relationship have discovered interleukin-17 (IL-17) cytokine as one of the pro-inflammatory mediators that play a crucial role in the initiation and progression of the chronic periodontal disease ...
Erry Mochamad Arief +4 more
doaj +1 more source
Is interleukin-17 implicated in early knee osteoarthritis pathogenesis as in rheumatoid arthritis?
Egyptian Rheumatology and Rehabilitation, 2022 Background Interleukin-17 (IL-17) is a cytokine that promotes activation of multiple catabolic pathways resulting in cartilage and tissue damage. It has features making it increasingly attractive as a biological marker, especially in rheumatoid arthritis
Hoda M. Abdel-Naby +3 more
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The Treatment with Interleukin 17 Inhibitors and Immune-Mediated Inflammatory Diseases
Current Issues in Molecular Biology, 2022 IL-17 inhibitors (IL-17i) are medicines used to treat dermatological and rheumatic diseases They belong to a class of medicines called biological disease-modifying anti-rheumatic drugs (bDMARDs).
Laura Țiburcă +6 more
doaj +1 more source
γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis. [PDF]
, 2018 γδ T cells have been implicated in inflammatory diseases as an important link between the innate and adaptive immune responses, however, their role in inflammatory arthritis remain unclear.
Adamopoulos, Iannis E +3 more
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Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression [PDF]
, 2015 The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i).
Cahn, Pedro +13 more
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Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
Advanced Biomedical Research, 2014 Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway ...
Rahim Farahani +4 more
doaj +1 more source
Interleukin-17A promotes parietal cell atrophy by inducing apoptosis [PDF]
, 2018 Background & Aims: Atrophic gastritis caused by chronic inflammation in the gastric mucosa leads to the loss of gastric glandular cells, including acid-secreting parietal cells.
Alderuccio +47 more
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Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul +13 more
wiley +1 more source
Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis [PDF]
, 2018 Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and ...
Ciccia F. +3 more
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