Results 71 to 80 of about 5,516,346 (290)

Interleukin 17A Contributes to Blood‐Brain Barrier Disruption of Hypothalamic Paraventricular Nucleus in Rats With Myocardial Infarction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Elevated inflammatory cytokines in the periphery have been identified as active contributors to neuroinflammation and sympathetic overactivity in heart failure (HF).
Yang Yu, Robert M. Weiss, Shun‐Guang Wei   +2 more
doaj   +1 more source

Critical Role of the Interleukin-17/Interleukin-17 Receptor Axis in Regulating Host Susceptibility to Respiratory Infection withChlamydiaSpecies [PDF]

Infection and Immunity, 2009
ABSTRACTThe specific contribution of interleukin-17/interleukin-17 receptor (IL-17/IL-17R)-mediated responses in regulating host susceptibility against obligatory intracellularChlamydiainfection was investigated in C57BL/6 and C3H/HeN mice duringChlamydia muridarumrespiratory infection.
Xiaohui, Zhou, Qiangwei, Chen, Jessica, Moore, Jay K, Kolls, Scott, Halperin, Jun, Wang   +5 more
openaire   +2 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Interleukin‐17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin‐17 receptors in rodents [PDF]

Arthritis & Rheumatism, 2012
AbstractObjectiveInterleukin‐17 (IL‐17) is considered a proinflammatory cytokine, but whether neuronal IL‐17 receptors contribute to the generation of arthritic pain is unknown. This study was undertaken to explore whether IL‐17A acts on neurons, whether it sensitizes joint nociceptors, and whether neutralization of IL‐17 is antinociceptive.MethodsWe ...
Frank, Richter, Gabriel, Natura, Matthias, Ebbinghaus, Gisela Segond, von Banchet, Susanne, Hensellek, Christian, König, Rolf, Bräuer, Hans-Georg, Schaible   +7 more
openaire   +2 more sources

Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia [PDF]

, 2012
<b>Objective—</b><p></p> The p75 neurotrophin receptor (p75^NTR) contributes to diabetes mellitus−induced defective postischemic neovascularization.
Spinetti, Gaia, Ambra Gotti, Losa, Sergio, Christa Noehammer, Ezio Faglia, Orazio Fortunato, Caporali, Andrea, Emanueli, Costanza, Nailor, Audrey, Cardinali, Alessandro Cardinali, Alessandro Cardinali, Manuela Hofner, Noehammer, Christa, Sergio Losa, Gotti, Ambra, Miller, Ashley M, Vierlinger, Klemens, Fortunato, Orazio, Ashley M. Miller, Tijana Mitić, Costanza Emanueli, Miller, Ashley M., Hofner, Manuela, Caporali, Andrea; id_orcid, Cardinali, Alessandro, Meloni, Marco, Paolo Madeddu, Gaia Spinetti, Faglia, Ezio, Klemens Vierlinger, Audrey Nailor, Mitić, Tijana, Andrea Caporali, Madeddu, Paolo, Marco Meloni   +34 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

The Inhibitory Effect of Rapamycin on Toll Like Receptor 4 and Interleukin 17 in the Early Stage of Rat Diabetic Nephropathy

Kidney & Blood Pressure Research, 2016
Background/Aims: There is increasing evidence showing that innate immune responses and inflammatory processes play an important role in the development and progression of diabetic nephropathy (DN).
Ruichao Yu, Hong Bo, Vincenzo Villani, Philip J. Spencer, Ping Fu   +4 more
doaj   +1 more source

Truncated Chicken Interleukin-1β with Increased Biologic Activity [PDF]

, 2003
Chicken interleukin-1β (ChIL-1β) is synthesized as a precursor molecule that unlike its mammalian counterpart, lacks a typical caspase-1 cleavage site. Therefore, it was unclear if proteolytic cleavage of ChIL-1β can occur and if cleavage might modulate ...
Erno Duda, Zsuzsa Gyorfy, Duda, Erno, Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Annette Ohnemus, Kaspers, Bernd, Gyorfy, Zsuzsa, Ohnemus, Annette, Bernd Kaspers   +10 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi, Forrest, A, Schroder, K, Forrest, Alistair, Kawai, J, Kawaji, H, Wells, Christine A, Faulkner, G, Carninci, P, Hume, DA, Carninci, Piero, Grimmond, SM, Himes, SR, Lo, Sandra, Hume, David, Schroder, Kate, Taylor, D, Grimmond, Sean M, Faulkner, Geoffrey, Chalk, Alistair, Kasukawa, T, Himes, S Roy, Grimmond, Sean, Kawai, Jun, Waddell, Nic, Lo, Yu-Lan Sandra, Hayashizaki, Yoshihide, Kasukawa, Takeya, Wells, Christine, Katayama, S, Hayashizaki, Y, Chalk, Alistair M, Katayama, Shintaro, Hume, David A, Chalk, AM, Taylor, Darrin, Kawaji, Hideya, Wells, CA, Waddell, N, Lo, S, Kai, C   +40 more
core   +1 more source