Results 81 to 90 of about 5,516,346 (290)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Characterization of a gp130 Signaling Receptor Polymorphism [PDF]

, 2013
We previously reported an association between human herpesvirus 8 (HHV-8) seroprevalence and increased prostate cancer risk among men on the Caribbean island of Tobago.
Kercher, Katherine
core  

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

, 2007
Interleukin-6 (IL-6) is a key inflammatory cytokine, signalling to most tissues by binding to a soluble IL-6 receptor (sIL-6r), making a complex with gp130.
A Murray, Henley, W, Bandinelli, S, S Rafiq, Rafiq, S, Weedon, MN, Guralnik, JM, Hurst, A, A-M Corsi, Ferrucci, L, K Stevens, S Bandinelli, M N Weedon, Corsi, A-M, L Ferrucci, Murray, A, D Melzer, W Henley, T M Frayling, J M Guralnik, A Hurst, Stevens, K, Melzer, D, Frayling, TM   +23 more
core   +1 more source

The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]

, 2007
CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Gu, Mei, Grammatopoulos, Dimitris, Markovic, Danijela, Slater, Donna, Newton, Rob, Vatish, Manu, Lehnert, Hendrik   +6 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Trypanosomiasis-induced Th17-like immune responses in carp [PDF]

, 2010
Background - In mammalian vertebrates, the cytokine interleukin (IL)-12 consists of a heterodimer between p35 and p40 subunits whereas interleukin-23 is formed by a heterodimer between p19 and p40 subunits.
B M Lidy Verburg-van Kemenade, Verburg-van Kemenade, B.M.L., Chadzinska Magdalena, Wiegertjes Geert F., Chadzinska, M.K., Huub F. J. Savelkoul, Scheer Marleen, Savelkoul, H.F.J., Scheer, M.H., Geert F Wiegertjes, Savelkoul Huub F. J., Bird, S., Maria J. S. L. Pontes, Ribeiro, Carla M. S., B. M. Lidy Verburg-van Kemenade, Wiegertjes, G.F., Savelkoul, Huub F. J., Carla M S Ribeiro, Scheer, Marleen, Marleen Scheer, Verburg-van Kemenade B. M. Lidy, Steve Bird, Maria J S L Pontes, Huub F J Savelkoul, Pontes, Maria J. S. L., Verburg-van Kemenade, B. M. Lidy, Ribeiro, C.M.S., Wiegertjes, Geert F., Bird Steve, Magdalena Chadzinska, Carla M. S. Ribeiro, Pontes, M.J.S.L., Ribeiro Carla M. S., Chadzinska, Magdalena, Pontes Maria J. S. L., Bird, Steve, Geert F. Wiegertjes   +36 more
core   +2 more sources

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Adverse Events and Immune Response in Psoriasis Patients Receiving Interleukin-17 Inhibitors

Acta Dermato-Venereologica
Interleukin-17 inhibitors are effective in psoriasis; however, they are associated with an increased risk of infections, particularly oral candidiasis, and new-onset/flares of inflammatory bowel disease.
Christopher Willy Schwarz, Charlotte Näslund-Koch, Claus Zachariae, Jakob Benedict Seidelin, Susanne Dam Nielsen, Sisse Rye Ostrowski, Karen Marie Thyssen Astvad, Inger Brock, Lars Iversen, Mads Kirchheiner Rasmussen, Nikolai Loft, Lone Skov   +11 more
doaj   +1 more source

Melatonin receptor 2 mediated spinal dorsal horn astrocytes IL-17 inhibition contributes to electroacupuncture analgesia in neuropathic pain rats

针刺研究, 2021
Objective To investigate the effect of electroacupuncture(EA) on pain behaviors and expression of spinal dorsal horn melatonin receptor 2(MT2) and interleukin-17(IL-17) in neuropathic pain rats, so as to explore its mechanism underlying pain relief ...
DENG Le-yan, ZHOU Sen, CHEN Qian-huang, DAI Qin-xue   +3 more
doaj  

Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.

PLoS ONE, 2014
Age-related macular degeneration (AMD) is a common yet complex retinal degeneration that causes irreversible central blindness in the elderly. Pathology is widely believed to follow loss of retinal pigment epithelium (RPE) and photoreceptor degeneration.
Daniel Ardeljan, Yujuan Wang, Stanley Park, Defen Shen, Xi Kathy Chu, Cheng-Rong Yu, Mones Abu-Asab, Jingsheng Tuo, Charles G Eberhart, Timothy W Olsen, Robert F Mullins, Gary White, Sam Wadsworth, Abraham Scaria, Chi-Chao Chan   +14 more
doaj   +1 more source