Results 61 to 70 of about 567,676 (278)
Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection. [PDF]
, 2016 Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods.
Belitskaya-Lévy, Ilana +8 more
core +3 more sources
Cancer‐killing, decoy‐resistant interleukin‐18 [PDF]
Immunology & Cell Biology, 2020 A recent paper by Zhou et al. describes a new engineered decoy-resistant interleukin-18 with potent antitumor activity and translational potential for cancer immunotherapy.
Kyohei Nakamura +2 more
openaire +3 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Jurnal Kedokteran dan KesehatanThe use of antipsychotic therapy is effective in managing symptoms and has become a cornerstone in the treatment of patients with schizophrenia. However, antipsychotics have side effects on the immune system, particularly affecting Interleukin 18 (IL-18)
Dita Hasni +2 more
doaj +1 more source
Linchuang shenzangbing zazhi, 2021 Objective To explore the serum expressions of interleukin-9（IL-9）,interleukin-18（IL-18）and interleukin-32（IL-32）in patients with multiple myeloma（MM）and examine their values in predicting renal injury.Methods Seventy-eight MM patients from January 2015 ...
Zhuang Ni-la +5 more
doaj
Inflammasomes driven inflammation in lung cancer revisited: a short review
Exploration of Immunology, 2023 Lung cancer is the leading cause of cancer-related deaths worldwide. The main risk factor for lung cancer is exposure to chemicals present in cigarettes and atmospheric pollutants, which, among other mechanisms, can increase the risk of cancer by ...
Vitor Rodrigues da Costa +5 more
doaj +1 more source
The proinflammatory cytokine interleukin 18 regulates feeding by acting on the bed nucleus of the stria terminalis [PDF]
, 2016 The proinflammatory cytokine IL-18 has central anorexigenic effects and was proposed to contribute to loss of appetite observed during sickness. Here we tested in the mouse the hypothesis that IL-18 can decrease food intake by acting on neurons of the ...
Alboni, Silvia +10 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Association of
Reproductive Biology and Endocrinology, 2012 Background Interleukin (IL)-18 is an important regulator of innate and acquired immune responses and has multiple roles in chronic inflammation and autoimmune disorders. Obesity is characterized by low- grade chronic inflammation.
Kim Hye-Lin +11 more
doaj +1 more source