Results 241 to 250 of about 36,414,078 (299)

Exploring PIM1 Kinase as a Therapeutic Target: Mechanisms and Strategies in Cancer Treatment. [PDF]

Int J Mol Sci
Zeng T, Liu H, Li Z, Liu T, Zhang K, Wang S.   +5 more
europepmc   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

B cells in cancer: functions, mechanisms and therapeutic advances. [PDF]

Signal Transduct Target Ther
Zhang H, Cheng K, Mo J, Chen M, Zhou Z, Wang Z, Yang Z, Chen X, Zhang W.   +8 more
europepmc   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Context-dependent immunomodulation by caspofungin: inflammatory attenuation involving spleen tyrosine kinase signaling in monocytic-cell systems versus pathogen-mediated immune amplification. [PDF]

Microlife
Itoh K, Iwasaki H, Ikawa M, Mitsuke Y.
europepmc   +1 more source

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

Developmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho, Prateek Arora, Ines J. Marques, María Galardi‐Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader   +6 more
wiley   +1 more source

Global Proteomic Analysis Reveals Inflammatory Pathway Modulation Associated with miR-146a in LPS-Stimulated Macrophages. [PDF]

Int J Mol Sci
Tangwattanachuleeporn M, Srichaimongkol A, Makjaroen J, Virakul S, Nanthawong S, Sun HS, Dewi NNA, Palaga T, Wongsurawat T, Leelahavanichkul A, Somparn P.   +10 more
europepmc   +1 more source

Toll-Like Receptors in the Mechanism of Hexabromocyclododecane-Induced Production of Pro-Inflammatory Cytokines. [PDF]

J Appl Toxicol
Zhu W, Seaton-Terry A, Townsend B, Hunter Z, Falconer-Turner A, Shahid SR, Whalen M.   +6 more
europepmc   +1 more source

Evaluating antioxidant treatment approaches for eosinophilic chronic sinusitis. [PDF]

Front Immunol
Kusunoki T, Joseph D, Ikeda K, You F, Inufusa H.   +4 more
europepmc   +1 more source

<i>In Silico</i> Methods Applied in Drug and Pesticide Discovery. [PDF]

Molecules
Borota A, Stegarus DP, Rivera Sanchez G.
europepmc   +1 more source