Results 11 to 20 of about 46,140 (235)

Contribution of interleukin-1beta in neuropathic pain

open access: greenChinese Journal of Contemporary Neurology and Neurosurgery, 2013
Interleukin-1beta (IL-1β), a pro-inflammatory cytokine, has been implicated in the development of peripheral and central sensitization that is charactistic of neuropathic pain.
Wei GUO
doaj   +2 more sources

Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease [PDF]

open access: bronzeJournal of Neurology, Neurosurgery & Psychiatry, 2003
Activated microglia, the resident macrophages of the brain, are a feature of Alzheimer's disease. Animal models suggest that when activated microglia are further activated by a subsequent systemic infection this results in significantly raised levels of interleukin 1beta within the CNS, which may in turn potentiate neurodegeneration.
Clive Holmes
openalex   +5 more sources

Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells [PDF]

open access: hybridEuropean Spine Journal, 2023
Abstract Purpose This study aims to analyze the effect of pro-inflammatory cytokine-stimulated human annulus fibrosus cells (hAFCs) on the sensitization of dorsal root ganglion (DRG) cells. We further hypothesized that celecoxib (cxb) could inhibit hAFCs-induced DRG sensitization. Methods
Junxuan Ma   +14 more
openalex   +7 more sources

IL-1beta promotes the age-associated decline of beta cell function

open access: yesiScience, 2021
Summary: Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice.
Marianne Böni-Schnetzler   +7 more
doaj   +1 more source

Total Triterpenes of Wolfiporia cocos (Schwein.) Ryvarden & Gilb Exerts Antidepressant-Like Effects in a Chronic Unpredictable Mild Stress Rat Model and Regulates the Levels of Neurotransmitters, HPA Axis and NLRP3 Pathway

open access: yesFrontiers in Pharmacology, 2022
Purpose:Wolfiporia cocos is frequently used in traditional Chinese medicine to treat depression. However, antidepressant-like effects of the main active ingredients of Wolfiporia cocos, total triterpenes of Wolfiporia cocos (TTWC), are not well studied ...
Xiang Pan   +11 more
doaj   +1 more source

Interleukin 1-beta analysis in chronically inflamed and healthy human dental pulp [PDF]

open access: yesVojnosanitetski Pregled, 2017
Background/Aim. Proinflammatory cytokines can act like endogenous pyrogen interleukin 1 (IL-1), interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF α) which regulate the synthesis of secondary mediators and other proinflammatory cytokines through ...
Šubarić Ljiljana   +6 more
doaj   +1 more source

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