Immunity, Inflammation and Disease, 2023 Objectives To explore pro‐inflammatory cytokines status in the tear fluid of patients with hyperuricemia and gout and its association with uric acid level.
Mian Wu +4 more
doaj +1 more source
The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]
, 2019 Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M. +7 more
core +1 more source
Optogenetic Stimulation Enhances Interleukin-1beta Levels in Cultured Neurons [PDF]
Biophysical Journal, 2011 The pro-inflammatory cytokine interleukin-1beta (IL-1) has a role in physiological regulation, e.g. sleep, and in pathology including the chronic inflammation associated sleep disorders and in the neuropathology of brain trauma, epilepsy and stroke. Sleep and inflammation are affected by cell activity. However, a mechanistic connection between specific
Sengupta, Parijat +3 more
openaire +1 more source
Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways [PDF]
, 2012 It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines.
A Bosutti +189 more
core +2 more sources
Cysteine redox potential determines pro-inflammatory IL-1beta levels.
PLoS ONE, 2009 BackgroundCysteine (Cys) and its disulfide, cystine (CySS) represent the major extracellular thiol/disulfide redox control system. The redox potential (E(h)) of Cys/CySS is centered at approximately -80 mV in the plasma of healthy adults, and oxidation ...
Smita S Iyer +7 more
doaj +1 more source
Folia Morphologica, 2021 BACKGROUND: Synovial cysts are currently classified as degenerative lesions affecting the joint capsule or adjacent structures. MATERIALS AND METHODS: In our study we describe the results obtained in an immunohistochemical study comprising 18 patients ...
S. Taurone +9 more
doaj +1 more source
Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]
, 2012 Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Bauer, Christian +4 more
core +1 more source
The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective [PDF]
, 2008 Elevation of the proinflammatory cytokine Interleukin-1 (IL-1) is an integral part of the local tissue reaction to central nervous system (CNS) insult.
Solomon S Shaftel +2 more
core +1 more source
Interleukin 1beta in serum of women with preterm uterine contractions
Journal of Obstetrics and Gynaecology, 1997 Preterm delivery is a major obstetric and public health problem, accounting for 50-70% of all perinatal deaths. An enzyme-linked immunoassay (ELISA) test was used to determine serum interleukin 1b (IL-1b) levels in 32 women with preterm contractions compared with 26 women in term labour and 11 normal preterm pregnant women.
B, Kaplan +5 more
openaire +2 more sources
The potential for dietary factors to prevent or treat osteoarthritis [PDF]
, 2014 Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping +8 more
core +1 more source