Results 51 to 60 of about 23,893 (178)

Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain. [PDF]

PLoS ONE, 2010
BACKGROUND: Neuropathic pain is a highly debilitating chronic pain following damage to peripheral sensory neurons and is often resistant to all treatments currently available, including opioids.
Shigeo Hasegawa, Yuta Kohro, Miho Shiratori, Satoshi Ishii, Takao Shimizu, Makoto Tsuda, Kazuhide Inoue   +6 more
doaj   +1 more source

Sex‐, Age‐, Lifestyle‐, and Comorbidity‐Specific Reference Values for Serum Cytokines in the Dutch General Population: Results From the PROFILES Registry

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Inflammation‐related biomarkers have been implicated in a wide range of cancer‐related symptoms and patient‐reported outcomes (PROs), including fatigue, pain, and depression. To interpret biomarker data among cancer patients, normative reference values from healthy populations are essential.
Dounya Schoormans, Nicole Horevoorts, Marije Oudejans, Marjo van de Waarenburg, Floortje Mols   +4 more
wiley   +1 more source

The effect of high-intensity functional training with thylakoid supplementation on interleukins-1beta and interleukins 8 in obese men [PDF]

Journal of Medicinal Plants
Background: Obesity is a widespread public health concern with a growing global prevalence, leading to an increased risk of chronic metabolic conditions.
Heidar EbadiAsl, Bahman Mirzaei, Arsalan Damirchi   +2 more
doaj  

Thrombospondin‐4 Regulates Lipopolysaccharide‐Induced Apoptosis and Inflammation in Nucleus Pulposus Cells via the Phosphatidylinositol 3‐Kinase/Protein Kinase B Pathway

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
ABSTRACT Objective This study investigated the expression profile of Thrombospondin‐4 (THBS4) in intervertebral disc degeneration (IDD) and clarify its regulatory role in lipopolysaccharide (LPS)‐induced apoptosis and inflammation in nucleus pulposus cells (NPCs) via the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (AKT) pathway.
Yang Shu, Chunhua Sun, Shi Chen
wiley   +1 more source

Association of severity of COPD with IgE and interleukin-1beta

Monaldi Archives for Chest Disease, 2016
Background. Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease characterised by airflow limitation. The role of various inflammatory mediators such as interleukin-1beta (IL-1β) and Immunoglobulin E (IgE) have been implicated
B. Singh, S. Arora, V. Khanna
doaj   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Pulmonary Exacerbations and Treatment in PCD: A Narrative Review

Pediatric Pulmonology, Volume 61, Issue 7, July 2026.
ABSTRACT Primary ciliary dyskinesia (PCD) is a rare genetic disorder that causes chronic lung disease. Patients with PCD often experience pulmonary exacerbations with worsening symptoms and lung function decline. This review provides an overview of the existing knowledge regarding the PEx in PCD and reveals understudied topics that should be addressed ...
Pinelopi Anagnostopoulou, Stephanie Thee, Panayiotis Kouis, Panayiotis Yiallouros   +3 more
wiley   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, Volume 67, Issue 6, Page 3226-3242, June 2026.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

Ausência de associação entre polimorfismo do gene da interleucina-1 beta e o prognóstico de pacientes com traumatismo crânio-encefálico grave Lack of association between interleukin-1 gene polymorphism and prognosis in severe traumatic brain injury patients

Revista Brasileira de Terapia Intensiva, 2009
OBJETIVO: O traumatismo crânio-encefálico é a principal causa de óbito em indivíduos com idade entre 1 a 45 anos. O desfecho do traumatismo crânio-encefálico pode estar relacionado, além de fatores pré-morbidade e gravidade do dano, com fatores genéticos.
Taís Frederes Krämer Alcalde, Andrea Regner, Edison Moraes Rodrigues Filho, Patrícia Corso Silveira, Gabriela Gonçalves Grossi, Daniel Simon   +5 more
doaj   +1 more source