Results 51 to 60 of about 44,626 (220)

Single nucleotide polymorphisms in IL-1A RS1800587, IL-1B RS1143634 and vitamin D receptor rs731236 in stage III grade B/C periodontitis

Balkan Journal of Medical Genetics, 2023
The purpose of the study is to determine the prevalence of interleukin (IL)-1A (rs1800587), IL-1B (rs1143634) and vitamin D receptor (VDR) (TaqI, rs731236) gene polymorphisms in the Turkish population and their association with Stage III Grade B/C ...
Özturk Özener H., Tacal Aslan B., Eken B.F., Agrali Ö.B., Yildrim H.S., Altunok E.Ç., Ulucan K., Kuru L.   +7 more
doaj   +1 more source

Is interleukin-1 beta a culprit in macrophage-adipocyte crosstalk in obesity? [PDF]

, 2015
Adipose tissue remodeling occurs in obesity, characterized by adipocyte hypertrophy and increased infiltration of macrophages which also shift to a proinflammatory phenotype.
Bing, Chen
core   +1 more source

GJD Modulates Cardiac/Vascular Inflammation and Decreases Blood Pressure in Hypertensive Rats

Mediators of Inflammation, 2022
Gedan Jiangya decoction (GJD) (aqueous ethanol extract), a traditional Chinese medicine formula which contain six botanical drugs (Uncaria rhynchophylla (Miq.) Miq., Salvia miltiorrhiza Bunge, Pueraria lobata (Willd.) Ohwi, Eucommia ulmoides Oliv ...
Shadi A. D. Mohammed, Hanxing Liu, Salem Baldi, Pingping Chen, Fang Lu, Shumin Liu   +5 more
doaj   +1 more source

Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes [PDF]

, 2012
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90366/1/j.1365-2249.2011.04535.x ...
Franchi, Luigi, Ozkurede, V. U.
core   +1 more source

Long‐lasting remodeling of astrocytes in an Scna1+/− mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a prototypical developmental and epileptic encephalopathy caused by mutations in the SCN1A gene, leading to loss of function of the voltage‐gated sodium channel Naᵥ1.1. The latter causes early onset drug‐resistant seizures and enduring cognitive and behavioral deficits.
Athénaïs Genin, Alicia Janvier, Tristan Moujellil‐Legagneur, Marine Blaquière, Alexis Chaussy, Romane Privé, Fabrice Duprat, Massimo Mantegazza, Etienne Audinat, Nicola Marchi, Noémie Cresto   +10 more
wiley   +1 more source

Zeolite abrogates cadmium-induced testicular damage in rats: implication of NF-κB/ TNF-α/IL-1β Pathway [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Cadmium (Cd) is an environmental pollutant affecting various tissues and organs, including the testis. Many studies demonstrated that Cd toxicity causes testicular impairment through oxidative stress and inflammatory action.
N.M. Ibrahim, A.M. Kandil, R.S. Ali, R. Hesham, S. El-Ashram, M.I. Alquraishi, R. Abdel-Gaber, M.A. Dkhil, A.A. Elhemiely   +8 more
doaj   +1 more source

Context-Dependent IL-1 mRNA-Destabilization by TTP Prevents Dysregulation of Immune Homeostasis Under Steady State Conditions

Frontiers in Immunology, 2020
The bioavailability of the major pro-inflammatory cytokines IL-1α and IL-1β is tightly controlled by transcription and post-translational processing to prevent hyperinflammation.
Lucy Sneezum, Kevin Eislmayr, Helene Dworak, Vitaly Sedlyarov, Anita Le Heron, Florian Ebner, Irmgard Fischer, Yoichiro Iwakura, Pavel Kovarik   +8 more
doaj   +1 more source

Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy. [PDF]

, 2019
BackgroundNeonatal seizures are associated with adverse neurologic sequelae including epilepsy in childhood. Here we aim to determine whether levels of cytokines in neonates with brain injury are associated with acute symptomatic seizures or remote ...
Barkovich, A James, Deng, Xutao, Ferriero, Donna M, Foster-Barber, Audrey, Glass, Hannah C, Numis, Adam L, Rogers, Elizabeth E   +6 more
core  

Nociceptors Are Interleukin-1β Sensors [PDF]

The Journal of Neuroscience, 2008
A cardinal feature of inflammation is heightened pain sensitivity at the site of the inflamed tissue. This results from the local release by immune and injured cells of nociceptor sensitizers, including prostaglandin E2, bradykinin, and nerve growth factor, that reduce the threshold and increase the excitability of the peripheral terminals of ...
Alexander M, Binshtok, Haibin, Wang, Katharina, Zimmermann, Fumimasa, Amaya, Daniel, Vardeh, Lin, Shi, Gary J, Brenner, Ru-Rong, Ji, Bruce P, Bean, Clifford J, Woolf, Tarek A, Samad   +10 more
openaire   +2 more sources

Berberine alleviates cell pyroptosis in diabetic retinopathy by regulating AKT1, JUN, and STAT3

Ibrain, EarlyView.
Berberine alleviates diabetic retinopathy by reducing pyroptosis through AKT1/JUN/STAT3 regulation, as validated in rat models via network pharmacology, molecular docking, and experimental assays. Abstract Berberine (BBR) exerts an effective protection for diabetic retinopathy (DR), but the underlying key molecular mechanism remains unknown; this study
Na Li, Ji‐Lin Chen, Yi‐Jian Sun, Jia‐Fan Sun, Fatin Athirah Pauzi, Song‐Lin Zhu, Amy Yi Hsan Saik, Alan Han‐Kiat Ong   +7 more
wiley   +1 more source