Results 11 to 20 of about 242,716 (208)

Degradation of Interleukin 1β by Matrix Metalloproteinases [PDF]

Journal of Biological Chemistry, 1996
Matrix metalloproteinases (MMPs) and interleukin 1 (IL-1) are implicated in inflammation and tissue destruction, where IL-1 is a potent stimulator of connective tissue cells to produce the extracellular matrix-degrading MMPs. Here, we report that IL-1beta, but not IL-1alpha, is degraded by MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), MMP-3 ...
Ito, A, Mukaiyama, A, Itoh, Y, Nagase, H, Thøgersen, Ida, Enghild, J J; id_orcid 0000-0001-9292-9172, Sasaguri, Y, Mori, Y   +7 more
openaire   +4 more sources

Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2003
Activated microglia, the resident macrophages of the brain, are a feature of Alzheimer's disease. Animal models suggest that when activated microglia are further activated by a subsequent systemic infection this results in significantly raised levels of interleukin 1beta within the CNS, which may in turn potentiate neurodegeneration.
Holmes, C., El-Okl, M., Williams, A.L., Cunningham, C., Wilcockson, D., Perry, V.H.   +5 more
openaire   +4 more sources

Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells. [PDF]

Mol Cancer, 2017
__Background:__ It is widely recognized that inflammation promotes breast cancer invasion and metastasis. Given the complex nature of the breast tumor inflammatory microenvironment, much remains to be understood of the molecular mechanisms that govern ...
Chung ST, Geerts D, Roseman K, Renaud A, Connelly L.   +4 more
europepmc   +2 more sources

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

GINGIVAL TISSUE IL-1beta AND PGE2 LEVELS IN PATIENTS WITH CHRONIC PERIODONTITIS AFTER ADDITIONAL THERAPY WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS [PDF]

Journal of IMAB, 2010
Background: The understanding of the pathogenesis of periodontitis makes various progresses in the last decades. Today it is well known that the synthesis of high levels of pro-inflammatory mediators from gingival tissues in response to ...
Christina Popova, Antoaneta Mlachkova
doaj   +1 more source

Effects of N-acetylcysteine on the inflammatory response and bacterial translocation in a model of intestinal obstruction and ischemia in rats

Acta Cirúrgica Brasileira, 2023
Purpose: To evaluate effect of N-acetylcysteine (NAC) associated with Ringer lactate or hypertonic saline in inflammation and bacterial translocation on experimental intestinal obstruction (IO). Methods: Wistar rats was subjected to IO.
Rafael Izar Domingues da Costa, Joao Marcos da Silva Fischer, Roberto Rasslan, Marcia Kiyomi Koike, Edvaldo Massazo Utiyama, Edna Frasson de Souza Montero   +5 more
doaj   +1 more source

Interleukin 1-beta (Il-1β) polymorphism and orthodontics: a systematic review

Revista Facultad de Odontología Universidad de Antioquia, 2019
Introduction: the aim of this systematic review is to explore the published literature to analyze the relationship between polymorphism of interleukin 1-beta (IL-1β) and orthodontics.
Juan Fernando Aristizábal, Héctor Ríos, Diego Rey, María Antonia Álvarez, Beatriz Parra-Patiño, Mario Ortiz   +5 more
doaj   +1 more source

The Association Between Shift Work and Immunological Biomarkers in Nurses

Frontiers in Public Health, 2020
Objectives: Shift work is associated with several negative health effects. The underlying pathophysiological mechanisms are unclear, but low-grade inflammation has been suggested to play a role.
Bjørn Bjorvatn, Bjørn Bjorvatn, John Axelsson, John Axelsson, Ståle Pallesen, Ståle Pallesen, Siri Waage, Siri Waage, Øystein Vedaa, Øystein Vedaa, Kjersti M. Blytt, Kjersti M. Blytt, Hogne V. Buchvold, Bente E. Moen, Eirunn Thun   +14 more
doaj   +1 more source

Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. [PDF]

PLoS Pathogens, 2009
The intraerythrocytic parasite Plasmodium -- the causative agent of malaria -- produces an inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is released into the circulation during erythrocyte lysis.
Marina Tiemi Shio, Stephanie C Eisenbarth, Myriam Savaria, Adrien F Vinet, Marie-Josée Bellemare, Kenneth W Harder, Fayyaz S Sutterwala, D Scott Bohle, Albert Descoteaux, Richard A Flavell, Martin Olivier   +10 more
doaj   +1 more source