Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice. [PDF]
PLoS ONE, 2009 Recent evidence suggests that interleukin-1beta (IL-1beta), which was originally identified as a proinflammatory cytokine, is also required in the brain for memory processes.
Virginie F Labrousse +6 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
GINGIVAL TISSUE IL-1beta AND PGE2 LEVELS IN PATIENTS WITH CHRONIC PERIODONTITIS AFTER ADDITIONAL THERAPY WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS [PDF]
Journal of IMAB, 2010 Background: The understanding of the pathogenesis of periodontitis makes various progresses in the last decades. Today it is well known that the synthesis of high levels of pro-inflammatory mediators from gingival tissues in response to ...
Christina Popova, Antoaneta Mlachkova
doaj +1 more source
Degradation of Interleukin 1β by Matrix Metalloproteinases [PDF]
Journal of Biological Chemistry, 1996 Matrix metalloproteinases (MMPs) and interleukin 1 (IL-1) are implicated in inflammation and tissue destruction, where IL-1 is a potent stimulator of connective tissue cells to produce the extracellular matrix-degrading MMPs. Here, we report that IL-1beta, but not IL-1alpha, is degraded by MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), MMP-3 ...
Ito, A +7 more
openaire +3 more sources
Acta Cirúrgica Brasileira, 2023 Purpose: To evaluate effect of N-acetylcysteine (NAC) associated with Ringer lactate or hypertonic saline in inflammation and bacterial translocation on experimental intestinal obstruction (IO). Methods: Wistar rats was subjected to IO.
Rafael Izar Domingues da Costa +5 more
doaj +1 more source
Interleukin 1-beta (Il-1β) polymorphism and orthodontics: a systematic review
Revista Facultad de Odontología Universidad de Antioquia, 2019 Introduction: the aim of this systematic review is to explore the published literature to analyze the relationship between polymorphism of interleukin 1-beta (IL-1β) and orthodontics.
Juan Fernando Aristizábal +5 more
doaj +1 more source
The Association Between Shift Work and Immunological Biomarkers in Nurses
Frontiers in Public Health, 2020 Objectives: Shift work is associated with several negative health effects. The underlying pathophysiological mechanisms are unclear, but low-grade inflammation has been suggested to play a role.
Bjørn Bjorvatn +14 more
doaj +1 more source
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. [PDF]
PLoS Pathogens, 2009 The intraerythrocytic parasite Plasmodium -- the causative agent of malaria -- produces an inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is released into the circulation during erythrocyte lysis.
Marina Tiemi Shio +10 more
doaj +1 more source
IL-1beta processing in host defense: beyond the inflammasomes. [PDF]
PLoS Pathogens, 2010 Stimulation and release of proinflammatory cytokines is an essential step for the activation of an effective innate host defense, and subsequently for the modulation of adaptive immune responses.
Mihai G Netea +5 more
doaj +1 more source
Maltol, a Natural Flavor Enhancer, Inhibits NLRP3 and Non-Canonical Inflammasome Activation
Antioxidants, 2022 Maltol (3-hydroxy-2-methyl-4-pyrone) is used widely as a food and cosmetic supplement, and it has antioxidant and anti-inflammatory activities. Inflammasome causes the maturation and secretion of interleukin (IL)-1β and -18 through the activation of ...
Huijeong Ahn +4 more
doaj +1 more source