Results 251 to 260 of about 26,112,494 (338)

Design, synthesis, and biological evaluation of novel 3-oxo-2,3-dihydropyridazine derivatives as interleukin-2-inducible T-cell kinase (ITK) inhibitors. [PDF]

RSC Adv
Tangallapalli S, Gundla R, Paidikondala K, Gurská S, Rampeesa NK, Anugu SR, Džubák P, Hajdúch M, Das V, Katari NK.   +9 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Comparative real-world outcomes of stage III melanoma patients treated with talimogene laherparepvec or interleukin 2. [PDF]

Ther Adv Med Oncol
Reitmajer M, Nanz L, Müller N, Leiter U, Amaral T, Aebischer V, Flatz L, Forschner A.   +7 more
europepmc   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Targeting interleukin-2-inducible T cell kinase ameliorates immune-mediated aplastic anemia. [PDF]

Cancer Immunol Immunother
Li W, Lian Y, Zhang L, Li R, Liang Q, Mao J, Qiu C, Li H, Huang K, Li Q, Shen Y, Yang F, Tian L, Xiao T, Gu S, Pan H, Gao Z, Zhao J, Fang L, Ge M, Yuan W, Chu Y, Shi J.   +22 more
europepmc   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy. [PDF]

Sci Adv
Yang K, Bai B, Li X, Rou W, Huang C, Lu M, Zhang X, Dong C, Qi S, Liu Z, Yu G.   +10 more
europepmc   +1 more source

Oncolytic adenovirus encoding variant interleukin-2 combined with chemotherapy enables PD-L1 inhibition in pancreatic cancer models. [PDF]

Cancer Immunol Immunother
Pakola SA, Ojala N, Kudling TV, Clubb JHA, Jirovec E, van der Heijden M, Arias V, Haybout L, Basnet S, Grönberg-Vähä-Koskela S, Quixabeira DCA, Santos JM, Cervera-Carrascon V, Hemminki O, Kanerva A, Mustonen H, Puolakkainen P, Seppänen H, Hemminki A.   +18 more
europepmc   +1 more source

An optimised whole blood interleukin-2 release assay is more sensitive than interferon-γ ELISpot for detecting and quantifying gluten-specific CD4⁺ T-cell responses in coeliac disease. [PDF]

Clin Transl Immunology
Moscatelli OG, Russell AK, Henneken LM, Hardy MY, Tye-Din JA.   +4 more
europepmc   +1 more source