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A Comprehensive Review of Low-Dose Interleukin-2 (IL-2) Therapy for Systemic Lupus Erythematosus: Mechanisms, Efficacy, and Clinical Applications. [PDF]
Farooq A+9 more
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Tumor-Localized Interleukin-2 and Interleukin-12 Combine with Radiation Therapy to Safely Potentiate Regression of Advanced Malignant Melanoma in Pet Dogs. [PDF]
Stinson JA+10 more
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Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+T cells
Capera J+7 more
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Interleukin-2–based therapies in cancer
Science Translational Medicine, 2022Molecular insights into the mechanism of beneficial and adverse effects of interleukin-2 (IL-2) have resulted in the development of improved IL-2 formulations with IL-2 receptor bias and tissue-targeting properties.
M. E. Raeber, Dilara Şahin, O. Boyman
semanticscholar +1 more source
Acta Clinica Belgica, 1987
SummaryDiscovered in 1976, the lymphokine interleukin-2, intensively studied during the last years, plays a major role in the regulation of the immune function. The authors reviewing its principal properties, anticipate forthcoming prospects of considerable implications in therapy.Acta Clin. Bclg. 42, 4: 255–68.
M. Hiden, P. Neve
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SummaryDiscovered in 1976, the lymphokine interleukin-2, intensively studied during the last years, plays a major role in the regulation of the immune function. The authors reviewing its principal properties, anticipate forthcoming prospects of considerable implications in therapy.Acta Clin. Bclg. 42, 4: 255–68.
M. Hiden, P. Neve
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Because of the ability of interleukin-2 (IL-2) to support the proliferation and activation of numerous types of immunocompetent cells and to support the survival of adoptively transferred lymphocytes, there has been considerable interest in its use in the immunotherapy of malignancies.
Jay P. Siegel, Roj K. Puri
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New England Journal of Medicine, 1987
We studied the effects of adoptive immunotherapy with lymphokine-activated killer (LAK) cells plus interleukin-2 or therapy with high-dose interleukin-2 alone in 157 patients with metastatic cancer for whom standard therapy had proved ineffective or no ...
S. Rosenberg+12 more
semanticscholar +1 more source
We studied the effects of adoptive immunotherapy with lymphokine-activated killer (LAK) cells plus interleukin-2 or therapy with high-dose interleukin-2 alone in 157 patients with metastatic cancer for whom standard therapy had proved ineffective or no ...
S. Rosenberg+12 more
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Regulation of Interleukin 2 Receptor Expression by Interleukin 2
Scandinavian Journal of Immunology, 1986The regulatory influence of Interleukin 2 (IL‐2) on the expression of IL‐2 receptors (IL.‐2R) was studied using long‐term cultured T‐cell lines and recombinant IL‐2 (r‐IL‐2). Three T‐cell lines with different growth requirements were used as model systems: insulin‐specific BK‐BI‐1.2 cells express IL‐2R transiently after antigenic restimulation ...
T. Diamantstein+3 more
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