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Journal of the National Cancer Institute, 1994
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of cancer have demonstrated that cellular immune reactions against established malignancy exist in humans.
S. Rosenberg +9 more
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BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of cancer have demonstrated that cellular immune reactions against established malignancy exist in humans.
S. Rosenberg +9 more
semanticscholar +1 more source
1985
Publisher Summary This chapter describes certain approaches, which are most useful in the purification and characterization of human IL-2 and which have general applicability throughout the lymphokine field. Interleukin 2 (IL-2, T cell growth factor) is situated at the center of the cascade of antigen-nonspecific factors released during an immune ...
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Publisher Summary This chapter describes certain approaches, which are most useful in the purification and characterization of human IL-2 and which have general applicability throughout the lymphokine field. Interleukin 2 (IL-2, T cell growth factor) is situated at the center of the cascade of antigen-nonspecific factors released during an immune ...
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Immunotherapy with Interleukin-2 [PDF]
, 1989 Chemotherapy is capable of producing durable responses in only a few types of advanced cancer and there is therefore an urgent need for alternative approaches to treatment. For decades, immunologists have held the hope that it might be possible to induce or augment a host antitumour response and produce immune-mediated disease regression.
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Interleukin 2: Biology and biochemistry
Journal of Clinical Immunology, 1983Since its discovery as a T-cell growth factor, interleukin 2 (IL-2) has attracted considerable scientific attention, not only as a useful reagent for the maintenance of large numbers of effector T lymphocytes but as a potentially potent immunoregulatory molecule, which could be of therapeutic usefulness in a number of clinical conditions.
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The role of interleukin-2 during homeostasis and activation of the immune system
Nature reviews. Immunology, 2012O. Boyman, J. Sprent
semanticscholar +1 more source
1985
Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Kathleen F. Bongiovanni +6 more
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Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Kathleen F. Bongiovanni +6 more
openaire +2 more sources