Results 91 to 100 of about 528,114 (310)

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

The Emerging Role of Interleukin-21 in Transplantation [PDF]

Journal of Clinical & Cellular Immunology, 2013
Since its discovery in 2000, IL-21 has been shown to play critical roles in the regulation of both innate and adaptive immune responses. IL-21 is produced predominantly by multiple effector CD4+ T-cell types [T helper 17 (Th17), follicular helper T (TFH), and other activated CD4+ cells] and NKT cells.
Aini, Xie, Eric Dale, Buras, Jiahong, Xia, Wenhao, Chen   +3 more
openaire   +2 more sources

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Elevated plasma interleukin 21 is associated with higher probability and severity of idiopathic membranous nephropathy

Journal of Laboratory Medicine, 2023
Interleukin 21 (IL-21) is a receptor participating in innate immunity and correlates with the activation of innate immune cells. We sought to investigate the role of plasma IL-21 in patients with idiopathic membranous nephropathy (IMN).
Liu Miao, Huang Di, Liang Enyu, Deng Bishun, Huang Huijie, Zhao Zilin, Deng Li, Wang Xiaowan, Lin Haibiao, Bao Kun, Xu Peng, He Min   +11 more
doaj   +1 more source

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]

, 2017
In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Deurzen, C.H.M. (Carolien) van, Foekens, J.A. (John), Grebenchtchikov, N. (Nicolai), Look, M.P. (Maxime), Magdolen, V., Marchi, T. (Tommaso) de, Martens, J.W.M. (John), Sieuwerts, A.M. (Anieta), Smid, M. (Marcel), Smits, J.G. (Jan G.), Sweep, F.C. (Fred), Timmermans, A.M. (Mieke), Umar, A. (Arzu)   +12 more
core   +1 more source

Cloning and characterization of an isoform of interleukin‐21 [PDF]

FEBS Letters, 2007
Interleukin‐21 (IL‐21) has pleiotropic functions on the cells, which play roles in both innate and acquired immunity, such as T cells, B cells, natural killer (NK) cells and dendritic cells. In this study we identified a novel isoform of IL‐21, IL‐21iso in human and mouse. IL‐21iso might be an alternative splicing variant form and the C‐terminal region
Rahman, Mizanur, Nara, Hidetoshi, Onoda, Tadashi, Araki, Akemi, Li, Jun, Hoshino, Tomoaki, Asao, Hironobu   +6 more
openaire   +2 more sources

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Role of interleukin-21 in primary knee osteoarthritis: a clinical, laboratory and radiological study in Assiut Governorate

Al-Azhar Assiut Medical Journal
Background and aim Primary osteoarthritis (OA) is the most frequent arthritis, causing mobility impairment, joint deformities, and compromising quality of life.
Mohamed I.M. Abdelkareem, Awad S. Abbas, Ahmed M. Salem, Rehab A.E. Elsayed   +3 more
doaj   +1 more source

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis [PDF]

, 2011
Background/Aims: The chromosome 4q27 region harboring IL2 and IL21 is an established risk locus for ulcerative colitis (UC) and various other autoimmune diseases.
Albers HM, Barrett JC, Barrett JC, Bergquist A, Bergquist A, Bo X, Burkhard Göke, Chapman R, Chen B, Christian Rust, Daha NA, Fay MP, Festen EA, Gerald Ulrich Denk, Gershwin ME, Gershwin ME, Glas J, Glas J, Henckaerts L, Hinks A, Hirschfield GM, Johannes Stallhofer, Jürgen Glas, Kaplan MM, Karlsen TH, Laurence A, Li Y, Liu Y, Loftus, Loftus EV, Maiti AK, Malek TR, Marquez A, McGuire HM, Peluso I, Rüdiger Paul Laubender, Saarinen S, Sadlack B, Saich R, Saraiva M, Sawalha AH, Sgouroudis E, Stephan Brand, Thomas Pusl, Todd JA, van Heel DA, Weismuller TJ, Yamanouchi J, Yang L, Zheng SG, Zhernakova A, Zhernakova A   +51 more
core   +1 more source