Results 131 to 140 of about 3,093,388 (334)

Autoimmune gastrointestinal complications in patients with Systemic Lupus Erythematosus: case series and literature review [PDF]

, 2016
The association of systemic lupus erythematosus (SLE) with gastrointestinal autoimmune diseases is rare, but has been described in the literature, mostly as case reports.
Agmon-Levin N, Ahmed QM, Akram S, Arnett FC, Bessone F, Breuer GS, Byun JY, Cabrera GE, Carmona-Fernandes D, Carone FA, Chebli JM, Chong WP, Chowdhary VR, Cortese AF, Cowling DC, Criş cov GI, Culp KS, D A Isenberg, De Jager PL, Denham JM, Dreiling DA, Dubois EL, Ebert EC, Efe C, Efe C, Einarsdottir E, Essaadouni L, Fernández Rodríguez AM, Ferreiros-Vidal I, Fina D, Floreani A, Freeman HJ, Gershwin ME, Gibson T, Grimbacher B, Gupta D, Hallegua DS, Hamed I, Han S, Harada K, Hennes EM, Her M, Homberg JC, Irving KS, Isenberg DA, Janssens P, Joske RA, Ju JH, Kapila N, Katsanos KH, Katsanos KH, Laing TJ, Lee C-K, Leggett BA, Leonard WJ, Levy C, Lohse AW, Ludvigsson JF, Mackay IR, Makol A, Matsumoto T, Medina F, Michalopoulos G, Miller MH, Miyazaki T, Muratori P, Nakou M, Nesher G, Netto AP, Nitzan O, Park SW, Pascual-Ramos V, Pisetsky DS, Pollak VE, Reifenstein EC, Rensch MJ, Reynolds JC, Rodriguez EA, Runyon BA, Rustgi AK, S Custódio Alves, S Fasano, Seelig R, Serrano López MC, Shapeero LG, Shizuma T, Shizuma T, Sparberg M, Steffan W, Sultan SM, Sánchez-Guerrero J, Takahashi A, Taourel P, Thomas JR, Tian X-P, van Hoek B, Vergani D, Vitali C, Yamashita H, Zheng R-H, Zizic TM, Zizic TM   +101 more
core   +1 more source

Plasma microRNA Signature as Predictive Marker of Clinical Response to Therapy During Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone, Alessandra Colamatteo, Teresa Micillo, Gianmarco Abbadessa, Silvia Garavelli, Clorinda Fusco, Claudia Russo, Francesco Perna, Federica Garziano, Claudia La Rocca, Maria Mottola, Giorgia Teresa Maniscalco, Simona Bonavita, Antonio Luca Spiezia, Alessia Castiello, Roberta Lanzillo, Vincenzo Brescia Morra, Claudio Procaccini, Paola de Candia, Giuseppe Matarese   +19 more
wiley   +1 more source

Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells.

Immunity, 2022
Isaak Quast, Alexandra R. Dvorscek, C. Pattaroni, Thiago M. Steiner, Craig I. McKenzie, Catherine Pitt, K. O’Donnell, Z. Ding, D. Hill, R. Brink, M. Robinson, D. Zotos, D. Tarlinton   +12 more
semanticscholar   +1 more source

Interleukin‐21 administration to aged mice rejuvenates their peripheral T‐cell pool by triggering de novo thymopoiesis

Aging Cell, 2016
The vaccination efficacy in the elderly is significantly reduced compared to younger populations due to thymic involution and age‐related intrinsic changes affecting their naïve T‐cell compartment.
E. Al-Chami, A. Tormo, S. Pasquin, R. Kanjarawi, S. Ziouani, M. Rafei   +5 more
semanticscholar   +1 more source

Observational Study of Tocilizumab in Children With Febrile Infection‐Related Epilepsy Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to assess the efficacy and safety of using tocilizumab in children with febrile infection‐related epilepsy syndrome (FIRES) and explore tocilizumab‐related changes in interleukin (IL)‐6 levels. Methods Patients with FIRES admitted to the Intensive Care Unit (ICU) of Beijing Children's Hospital were retrospectively ...
Yushan He, Jie Wu, Chaonan Fan, Zheng Li, Jun Liu, Kechun Li, Quan Wang, Suyun Qian   +7 more
wiley   +1 more source

Association between interleukin 21 and Graves’ disease

Genetics and Molecular Research, 2011
Graves' disease (GD) is an organ-specific autoimmune thyroid disease; 25-50% of GD patients will develop Graves' ophthalmopathy (GO). The etiology of GD and GO may be multifactorial, but the immune response plays a central role. Many studies have reported that IL-21 has crucial roles in autoimmune diseases.
T. Guo, Huiying Jia, Z.G. Zhang, X.J. Gu, G. Ning, Yueran Zhao, B. Cui   +6 more
openaire   +3 more sources

Involvement of interleukin-21 in the regulation of colitis-associated colon cancer [PDF]

, 2011
IL-21 expression is increased in the gut of patients with colitis-associated colon cancer, and genetic ablation or antibody neutralization of IL-21 reduces tumor size and inflammation in mice treated with dextran sulfate sodium and ...
Angela Rotondi, Angelamaria Rizzo, Atreya, Becker, Buonocore, Caprioli, Carmine Stolfi, Caruso, Di Carlo, Eleonora Franzè, Erdman, Fantini, Fina, Flavio Caprioli, Francesco Pallone, Furukawa, Giovanni Monteleone, Greten, Greten, Grivennikov, Gupta, Hirahara, Ishibashi, Ivan Monteleone, Jinushi, Liu, Luana Franceschilli, Ma, Maniati, Mantovani, Massimiliano Sarra, Massimo Claudio Fantini, Monteleone, Monteleone, Monteleone, Pesce, Pierpaolo Sileri, Popivanova, Roberta Caruso, Rutter, Schmidt, Sica, Skak, Spolski, Stefano Ferrero, Tanaka, Terzic, Thomas T. MacDonald, Thompson, Vallabhapurapu, Wang, Wang, Wolf, Wu, Yu   +54 more
core   +2 more sources

High‐Efficacy Treatment in Neuromyelitis Optica Specturm Disorder Patients With Seropositive AQP4 Antibodies—A Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To compare the effectiveness of high‐efficacy treatments (HET) and low‐efficacy treatments (LET) in NMOSD patients with anti‐aquaporin‐4 antibodies (AQP4‐ab). Methods In this multi‐center study, we analyzed 183 AQP4‐ab seropositive NMOSD patients who received immunosuppressive treatments (IST).
Xiang Li, Binbin Xue, Jia Li, Dewei Xie, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Xu Zhang, Junhui Xia, Jie Lin   +10 more
wiley   +1 more source

Interleukin (IL)-21 in Inflammation and Immunity During Parasitic Diseases

Frontiers in Cellular and Infection Microbiology, 2019
Parasitic diseases cause significant morbidity and mortality in the developing and underdeveloped countries. No efficacious vaccines are available against most parasitic diseases and there is a critical need for developing novel vaccine strategies for ...
Shahram Solaymani-Mohammadi, Lars Eckmann, Steven M. Singer   +2 more
doaj   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source