Results 141 to 150 of about 3,093,388 (334)

Upregulated Interleukin 21 Receptor Enhances Proliferation and Epithelial-Mesenchymal Transition Process in Benign Prostatic Hyperplasia

Frontiers in Endocrinology, 2019
Background: Interleukins (ILs) and related chronic inflammation have been found to contribute to the development of benign prostatic hyperplasia (BPH) in recent decades.
Deqiang Xu, Ping Chen, He Xiao, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang   +5 more
doaj   +1 more source

Th17, intestinal microbiota and the abnormal immune response in the pathogenesis of celiac disease [PDF]

, 2015
Celiac disease (CD) is an autoimmune enteropathy induced by the ingestion of gluten in genetically predisposed individuals who carry the HLA-DQ2 or -DQ8 alleles.
Cicerone, Clelia, Nenna, Raffaella, Pontone, Stefano   +2 more
core  

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]

, 2017
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P., An, Zhiqiang, DePhillips, Pete A., Freed, Daniel C., Fu, Tong-Ming, Ha, Sha, Hamm, Melissa, Li, Fengsheng, Loughney, John W., McLellan, Jason S., McVoy, Michael A., Nickle, David C., Rustandi, Richard R., Tang, Aimin, Troutman, Matthew C., Vlasak, Josef, Wang, Dai, Wang, I-Ming, Zhang, Ningyan, Zhu, Hua   +19 more
core   +3 more sources

Association of Higher Levels of High‐Sensitivity C‐Reactive Protein With Future Development of Psoriatic Arthritis in Psoriasis: A Prospective Cohort Study

Arthritis Care &Research, EarlyView.
Objective We aimed to assess whether high‐sensitivity C‐reactive protein (hsCRP) levels could predict the development of psoriatic arthritis (PsA) in patients with psoriasis. Methods We analyzed data from a prospective cohort of patients with psoriasis without PsA at enrollment.
Lihi Eder, Xianwei Li, Vinod Chandran, Cheryl F. Rosen, Richard J. Cook, Dafna D. Gladman   +5 more
wiley   +1 more source

Progress of IL-21 and Tfh Mediated Immunotherapy in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer
Non-small cell lung cancer (NSCLC) is a prevalent and aggressive global malignancy. Conventional surgical treatments, radiotherapy, chemotherapy, and targeted therapies often fall short in halting disease progression due to inherent limitations ...
Xingkai LIU, Yifan ZHANG, Xin ZHANG, Gonghao HE, Wenke CAI   +4 more
doaj   +1 more source

Toll-like receptor 9 activation enhances B cell activating factor and interleukin-21 induced anti-proteinase 3 autoantibody production in vitro.

Rheumatology, 2016
OBJECTIVES Granulomatosis with polyangiitis (GPA) is a relapsing small-vessel vasculitis characterized by circulating ANCA against PR3. The mechanisms that trigger PR3-ANCA production are unknown. The aim of this study was to determine whether endogenous
N. Lepse, Judith Land, A. Rutgers, C. Kallenberg, C. Stegeman, W. Abdulahad, P. Heeringa   +6 more
semanticscholar   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response [PDF]

, 2013
Objective: Interleukin-21 (IL-21) is a proinflammatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still unclear.
Carvello, Michele, Chengwen, Liu, Du, Ming, Fiorina, Paolo, Hwu, Patrick, Kleffel, Sonja Beate, Lee, Kang Mi, Leonard, Warren J., Markmann, James F., Mfarrej, Bechara G., Petrelli, Alessandra, Sayegh, Mohamed Hassan, Secchi, Antonio, Tezza, Sara, Vergani, Andrea, Young, Deborah, Zajac, Allan J.   +16 more
core   +1 more source

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis

SpringerPlus, 2016
Background and aimsRecently, the number of follicular helper T (Tfh) cells expressing interleukin (IL)-21 was found to increase in peripheral blood of human and murine models of autoimmune hepatitis (AIH).
K. Abe, A. Takahashi, Hiromichi Imaizumi, M. Hayashi, Ken Okai, Y. Kanno, H. Watanabe, H. Ohira   +7 more
semanticscholar   +1 more source