Results 231 to 240 of about 73,008,320 (286)

Animal models of anemia of inflammation: Methodological advances, limitations, and translational applications. [PDF]

Animal Model Exp Med
Cheng J, Zhou X, Liu Q, Liu Z, Wu H.
europepmc   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Dynamic Gut-Lung Microbiome Interactions Beyond Dysbiosis Across the Course of COPD. [PDF]

Int J Chron Obstruct Pulmon Dis
Ren Y, Hu Y, Qin H, Zhang Y, Zhao H.
europepmc   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Serum Cytokine Profiling in Pancreatic Ductal Adenocarcinoma: A Pilot Study of Candidate Discriminators, Sex Differences and Altered Co-Regulation. [PDF]

Biomolecules
García-Gómez J, Agredano-Pérez S, Rubio-Delgado DA, Aguilar-Lemarroy A, Jave-Suárez LF, Guevara-Hernández SN, Bravo-Cuéllar A, Méndez-Clemente AS, Hernández-Flores G, Villaseñor-García MM.   +9 more
europepmc   +1 more source

An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

Advanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie, Yan Li, Guangyao Li, Ying Chen, Huaming Yang   +4 more
wiley   +1 more source

Efficacy of nutraceuticals as adjunctive therapies in autoimmune diseases: A systematic review of clinical trials. [PDF]

Bioimpacts
Iglesias JCF, Méndez López LF.
europepmc   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Severe Chronic Rhinosinusitis with Nasal Polyps: From IL-5-Driven Pathogenetic Mechanisms to Clinical Management in the Italian Clinical Setting. [PDF]

J Inflamm Res
Cavaliere C, Cantone E, Pipolo C, Ottaviano G, Canevari FRM, La Mantia I, Maggiore G, Brembilla G, Mollo MR, Shalby O, Pasquini E, Pecorari G, Seccia V, De Corso E.   +13 more
europepmc   +1 more source

Exploratory Analysis of the Innate Immune System in Aortic Stenosis Patients With and Without ASCVD. [PDF]

JACC Basic Transl Sci
van Broekhoven A, van Doorn EPM, Broeders W, Cetinyurek-Yavuz A, Zegers ES, Netea MG, Vonk ABA, van Royen N, Niessen HWM, Cornel JH, Riksen NP, El Messaoudi S.   +11 more
europepmc   +1 more source