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Interleukin 22 and its association with neurodegenerative disease activity [PDF]
Frontiers in Pharmacology, 2022 It is worth noting that neuroinflammation is well recognized as a symptom of neurodegenerative diseases (NDs). The regulation of neuroinflammation becomes an attractive focus for innovative ND treatment technologies.
Wenjian Chen +8 more
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Interleukin-22 Inhibits Bleomycin-Induced Pulmonary Fibrosis [PDF]
Mediators of Inflammation, 2013 Pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Recent insight has suggested that early injury/inflammation of alveolar epithelial cells could lead to dysregulation of tissue repair driven by multiple ...
Minrui Liang +11 more
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Protective function of interleukin‐22 in pulmonary fibrosis [PDF]
Clinical and Translational Medicine, 2021 Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive scarring disease with unknown etiology. The evidence of a pathogenic role for transforming growth factor‐beta (TGF‐β) in the development and progression of IPF is overwhelming.
Peiyu Gu +12 more
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Plasma interleukin-22 concentration and disease activity in inflammatory bowel disease [PDF]
Scientific ReportsThe relationship between interleukin-22 and clinical characteristics of patients with inflammatory bowel disease is uncertain. We sought to determine whether plasma interleukin-22 concentrations are associated with disease activity in a large population ...
Claudia Cabrera +10 more
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A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice [PDF]
Frontiers in Immunology, 2022 IntroductionThe pathogenic mechanisms of diabetic nephropathy (DN) include podocyte injury, inflammatory responses and metabolic disorders. Although the antagonism of Angiopoietin-like protein 3 (ANGPTL3) can alleviate proteinuria symptoms by inhibiting ...
Qianqian Ma +16 more
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Lipid-encapsulated mRNA encoding an extended serum half-life interleukin-22 ameliorates metabolic disease in mice [PDF]
Molecular MetabolismObjective: Interleukin (IL)-22 is a potential therapeutic protein for the treatment of metabolic diseases such as obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease due to its involvement in multiple cellular pathways ...
Susanna Canali +17 more
doaj +2 more sources
Interleukin 18 and interleukin 22 as important immune markers in patients with tuberculosis [PDF]
E3S Web of Conferences, 2023 Tuberculosis (TB) is a lung infection caused by the bacterium Mycobacterium tuberculosis (MTB). TB is a leading cause of death globally, accounting for approximately 1.5 million deaths per year.
Kamoona Firas Mohammad Hussein +1 more
doaj +1 more source
Frontiers in Immunology, 2021 Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE). Our previous studies demonstrated increased serum and renal Interleukin (IL)-22 in LN patients and MRL/lpr mice.
Lingzhen Hu +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Mucosal tissue forms the first line of defense against pathogenic microorganisms. Cellular damage in the mucosal epithelium may induce the interleukin (IL)-22-related activation of many immune cells, which are essential for maintaining the mucosal ...
Yoshie Takahashi +7 more
doaj +1 more source
Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]
, 2013 Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core +10 more sources