Applied Sciences, 2021 Indigo naturalis, which is extracted from the leaves and branches of Baphicacanthus cusia (Nees) Bremek, has traditionally been used to treat psoriasis.
Ly Thi Huong Nguyen +4 more
doaj +1 more source
The role of Interleukin-22 in severe acute pancreatitis. [PDF]
Mol MedAbstractSevere acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a potential systemic inflammatory response that leads to organ failure with increased mortality and a bleak prognosis. Interleukin-22 (IL-22) is a cytokine that may have a significant role in SAP.
Yang H +7 more
europepmc +4 more sources
Human gut dendritic cells drive aberrant gut-specific T-cell responses in ulcerative colitis, characterized by increased IL-4 production and loss of IL-22 and IFNγ [PDF]
, 2014 The pathogenesis of inflammatory bowel disease is incompletely understood but results from a dysregulated intestinal immune response to the luminal microbiota. CD4 T cells mediate tissue injury in the inflammatory bowel disease-associated immune response.
Al-hassi, Hafid O. +12 more
core +1 more source
Analysis of Interleukin 22 Gene Expression in Helicobacter pylori-Infected Patients With Inflammation and Peptic Ulcer Compared to Uninfected Controls [PDF]
Journal of Shahrekord University of Medical SciencesBackground and aims: Inflammation is a key feature of Helicobacter pylori infection and its associated complications, gastritis, and gastrointestinal ulcers.
Mehrnoosh Haghighian +2 more
doaj +1 more source
The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of Collagen-Induced Arthritis [PDF]
, 2014 S-62 is a phosphorylcholine (PC)-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that acts to modulate the host immune response to promote the establishment of chronic helminth infection.
Harnett, Margaret +2 more
core +1 more source
Acta Dermato-Venereologica, 2021 Current understanding of the underlying pathophysiology of hidradenitis suppurativa (HS) links the disease with proinflammatory activation and autoimmune processes.
Malgorzata Ponikowska +4 more
doaj +1 more source
The regulation of host defences to infection by the microbiota [PDF]
, 2016 The skin and mucosal epithelia of humans and other mammals are permanently colonised by large microbial communities (the microbiota). Due to this life-long association with the microbiota, these microbes have an extensive influence over the physiology of
Brown, RL, Clarke, TB
core +1 more source
NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice [PDF]
, 2018 Innate lymphoid cells (ILCs) producing IL-22 and/or IL-17, designated as ILC3, comprise a heterogeneous subset of cells involved in regulation of gut barrier homeostasis and inflammation.
Kanno, Yuka +7 more
core +1 more source
Biological and pathological activities of interleukin-22 [PDF]
Journal of Molecular Medicine, 2016 Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several types of immune cells including IL-22(+)CD4(+) T cells (Th22) and IL-22 expressing innate leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival, and proliferation ...
Mirna, Perusina Lanfranca +4 more
openaire +2 more sources
From intestinal dysbiosis to alcohol-associated liver disease [PDF]
Clinical and Molecular Hepatology, 2020 Alcohol-associated intestinal dysbiosis and bacterial overgrowth can lead to a dysregulation of tryptophan metabolism and lower production of indoles. Several of these indole derivatives are aryl hydrocarbon receptor ligands that, in turn, are involved ...
Beatriz Garcia Mendes, Bernd Schnabl
doaj +1 more source