Results 21 to 30 of about 539,865 (299)
Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study [PDF]
, 2012 Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease.
Bachmann, Malte +11 more
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Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis. [PDF]
, 2012 OBJECTIVE: The intestinal inflammation observed in patients with ankylosing spondylitis (AS) is characterized by an overexpression of interleukin-23 (IL-23). IL-23 is known to regulate IL-22 production through lamina propria NKp44+ natural killer (NK)
Accardo Palumbo A +9 more
core +1 more source
Annals of Hepatology, 2016 Background and aims. Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver in which the immunological mechanisms involved in tissue destruction and/or repair are still unclear. Different pro-inflammatory cytokines have been shown to
Pablo Thomas-Dupont +8 more
doaj +1 more source
Deciphering the role of interleukin-22 in metabolic alterations [PDF]
, 2015 Inflammatory processes and metabolic alterations are supposed to substantially interact. Recently, cumulating reports describe a profound role of interleukin(IL)-22 in this relationship.
Sabat, Robert, Wolk, Kerstin
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Tristetraprolin regulation of interleukin-22 production [PDF]
Scientific Reports, 2015 AbstractInterleukin (IL)-22 is a STAT3-activating cytokine displaying characteristic AU-rich elements (ARE) in the 3′-untranslated region (3′-UTR) of its mRNA. This architecture suggests gene regulation by modulation of mRNA stability. Since related cytokines undergo post-transcriptional regulation by ARE-binding tristetraprolin (TTP), the role of this
Härdle, Lorena +8 more
openaire +3 more sources
Role of Interleukin-22 in ulcerative colitis
Biomedicine & Pharmacotherapy, 2023 Ulcerative Colitis (UC) is a chronic disease, in the progression of which an immune overreaction may play an important role. IL-22 is a member of the IL-10 superfamily of cytokines and is pleiotropic in immune regulation and inflammatory responses. IL-22 can produce protective effects, promote wound healing and tissue regeneration, while it can also ...
Nan Zhao +6 more
openaire +2 more sources
Interleukin-22 acts as a mitochondrial protector
Theranostics, 2020 Interleukin (IL)-22 has been increasingly recognized as a promising therapeutic option for various types of diseases. This commentary summarizes the novel mechanistic aspects of IL-22 for the treatment of liver diseases including the study by Chen et al.
Hwang, Seonghwan, Feng, Dechun, Gao, Bin
openaire +2 more sources
Interleukin-22 Influences the Th1/Th17 Axis
Frontiers in Immunology, 2021 Interleukin-22 (IL-22) is secreted by a wide range of immune cells and its downstream effects are mediated by the IL-22 receptor, which is present on non-immune cells in many organs throughout the body.
Hannes Lindahl, Tomas Olsson
doaj +1 more source
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core +1 more source
Role of Interleukin-22 in liver diseases [PDF]
Inflammation Research, 2014 Interleukin (IL)-22, originally referred to as IL-TIF for IL-10-related T cell-derived inducible factor, is a member of the IL-10-like cytokine family. IL-22 is highly expressed by Th17 cells and is tightly linked to chronic inflammation, including inflammatory bowel disease and local intestinal inflammation among others.A PubMed and Web of Science ...
Pan, Chun-xiao +5 more
openaire +2 more sources