Results 1 to 10 of about 481 (112)
Brazilian Journal of Otorhinolaryngology, 2021 Chronic rhinosinusitis is a multifactorial disease whose pathogenesis, influenced by both genetic and environmental factors, is still unclear. Previous genetic studies have shown that patients with chronic rhinosinusitis have reduced expression of the Interleukin-22 (IL-22) gene.Identify and compare the frequency of polymorphisms in the IL22RA1 gene ...
Vanessa R. Pires Dinarte +5 more
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Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection [PDF]
Frontiers in Immunology, 2022 The new pandemic virus SARS-CoV-2 is characterized by uncontrolled hyper-inflammation in severe cases. As the IL-22/IL-22R1 axis was reported to be involved in inflammation during viral infections, we characterized the expression of IL-22 receptor1, IL-22 and IL-22 binding protein in COVID-19 patients.
Nurhan Albayrak +12 more
openaire +4 more sources
Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation [PDF]
Frontiers in Immunology, 2020 Airborne ozone exposure causes severe lung injury and inflammation. The aryl hydrocarbon Receptor (AhR) (1), activated in pollutant-induced inflammation, is critical for cytokine production, especially IL-22 and IL-17A. The role of AhR in ozone-induced lung inflammation is unknown. We report here that chronic ozone exposure activates AhR with increased
Chloé Michaudel +14 more
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The pathogenic role of interleukin-22 and its receptor during UVB-induced skin inflammation
PLOS ONE, 2017 Recent studies show that IL-22, a cytokine produced by activated CD4+ T cells and NK cells, plays a pathogenic role in acute and chronic skin diseases. While IL-22 is produced by immune cells, the expression of IL-22Rα, the functional subunit of IL-22R, is mostly restricted to non-hematopoietic cells in organs such as the skin and pancreas. Although it
Yejin Kim +6 more
openaire +4 more sources
PLOS ONE, 2016 IL-22 is a pro- and anti-inflammatory cytokine that is mainly produced by T cells and NK cells. Recent studies have reported the increased number of IL-22 producing T cells in patients with autoimmune noninfectious uveitis; however, the correlation between IL-22 and uveitis remains unclear.
Kim, Yejin +10 more
openaire +5 more sources
Clinical and Experimental Obstetrics & Gynecology, 2023 Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms in ITP to generate ideas for the pathogenesis and etiological investigation of the disease ...
Qian-qian Fan, Rong-xia He
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Gut MicrobesThe gut microbiota constitutes a complex ecosystem essential for host defense against infection and immune system maturation. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by a severe inflammation of the intestine, arising from dysregulated control of host-microbiota crosstalk. However, neither the
Dupraz, Louise +18 more
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AL-Kindy College Medical JournalBackground: Interleukin-22 is an effector cytokine belongs to the IL-10 family. Signaling of this cytokine control tumor development by boosting cancerous cells growth. Toll-like receptor-2 act key function in activation of tumor cell proliferation besides increasing tumor cell invasion.
Ikram Khazal Qasim Al-Hasso
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Frontiers in Immunology, 2021 Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE). Our previous studies demonstrated increased serum and renal Interleukin (IL)-22 in LN patients and MRL/lpr mice.
Lingzhen Hu +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Mucosal tissue forms the first line of defense against pathogenic microorganisms. Cellular damage in the mucosal epithelium may induce the interleukin (IL)-22-related activation of many immune cells, which are essential for maintaining the mucosal ...
Yoshie Takahashi +7 more
doaj +1 more source