Results 21 to 30 of about 615,879 (297)

Interleukin-22 Forms Dimers that are Recognized by Two Interleukin-22R1 Receptor Chains [PDF]

Biophysical Journal, 2008
Interleukin-22 (IL-22) is a class 2 cytokine whose primary structure is similar to that of interleukin 10 (IL-10) and interferon-gamma (IFN-gamma). IL-22 induction during acute phase immune response indicates its involvement in mechanisms of inflammation.
de Oliveira Neto, Mario, Ferreira, José Ribamar, Colau, Didier, Fischer, Hannes, Nascimento, Alessandro S, Craievich, Aldo F, Dumoutier, Laure, Renauld, Jean-Christophe, Polikarpov, Igor   +8 more
openaire   +3 more sources

Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defence [PDF]

European Respiratory Journal, 2015
Chronic obstructive pulmonary disease (COPD) is punctuated by episodes of infection-driven acute exacerbations. Despite the life-threatening nature of these exacerbations, the underlying mechanisms remain unclear, although a high number of neutrophils in the lungs of COPD patients is known to correlate with poor prognosis.
Guillon, Antoine, Jouan, Youenn, Brea, Deborah, Gueugnon, Fabien, Dalloneau, Emilie, Baranek, Thomas, Henry, Clémence, Morello, Eric, Renauld, Jean-Christophe, Pichavant, Muriel, Gosset, Philippe, Courty, Yves, Diot, Patrice, Si-Tahar, Mustapha   +13 more
openaire   +2 more sources

Interleukin-22 receptor is overexpressed in nonsmall cell lung cancer and portends a poor prognosis [PDF]

European Respiratory Journal, 2016
The recent decade has witnessed a change of view about cancer mechanisms. Considerable evidence now suggests that the tumour microenvironment status is well correlated with disease outcome. The presence of particular immune cell types or molecules determines whether a pro- or antitumour immune response predominates within the microenvironment [1 ...
Guillon, A., Gueugnon, F., Mavridis, K., Dalloneau, E., Jouan, Y., Diot, P., Heuzé-Vourc'h, N., Courty, Y., Si-Tahar, M.   +8 more
openaire   +3 more sources

Interleukin-22 Mediates the Chemotactic Migration of Breast Cancer Cells and Macrophage Infiltration of the Bone Microenvironment by Potentiating S1P/SIPR Signaling

Cells, 2020
The interleukin-22 (IL-22) signaling pathway is well known to be involved in the progression of various cancer types but its role in bone metastatic breast cancer remains unclear.
Eun-Young Kim, Bongkun Choi, Ji-Eun Kim, Si-On Park, Sang-Min Kim, Eun-Ju Chang   +5 more
doaj   +1 more source

The Role of T Helper 22 Cells in Dermatological Disorders

Frontiers in Immunology, 2022
T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22
Yu Pan, Yu Pan, Dan Du, Lian Wang, Xiaoyun Wang, Xiaoyun Wang, Xiaoyun Wang, Gu He, Gu He, Gu He, Xian Jiang, Xian Jiang, Xian Jiang   +12 more
doaj   +1 more source

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]

, 2009
Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core   +1 more source

Interleukin 22 Receptor 1 Expression in Pancreas Islets

Pancreas, 2008
Interleukin (IL) 22 is a recently identified T-cell-derived cytokine. IL-22 binds at the cell surface to a heterodimer receptor complex composed of IL-22 receptor (R) 1 and IL-10R2. In this study, we performed immunohistochemical analyses for IL-22R1 expression in human pancreatic tissue.Normal human pancreatic tissue (n = 8) was immunostained with ...
Makoto, Shioya, Akira, Andoh, Satoe, Kakinoki, Atsushi, Nishida, Yoshihide, Fujiyama   +4 more
openaire   +3 more sources

Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy

Cell & Bioscience, 2021
Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body.
Xiuyun Xuan, Lin Zhang, Chunxia Tian, Ting Wu, Haihua Ye, Juanmei Cao, Fangqi Chen, Yan Liang, Huilan Yang, Changzheng Huang   +9 more
doaj   +1 more source

The role of the novel Th17 cytokine IL-26 in intestinal inflammation [PDF]

, 2008
Background and aims: Interleukin 26 (IL-26), a novel IL-10-like cytokine without a murine homologue, is expressed in T helper 1 (Th1) and Th17 cells. Currently, its function in human disease is completely unknown. The aim of this study was to analyse its
Auernhammer, Christoph J., Beigel, Florian, Brand, Stephan, Dambacher, J., Diepolder, Helmut M., Göke, Burkhard, Toni, Enrico N. de, Zitzmann, K.   +7 more
core   +1 more source

Interleukin‐22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription‐3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
BACKGROUND Interleukin (IL)‐22, a member of the IL‐10 cytokine family, is the only known cytokine that is secreted by immune cells but does not target immune cells; it mainly targets epithelial cells.
Jinya Takahashi, Mai Yamamoto, Hideo Yasukawa, Shoichiro Nohara, Takanobu Nagata, Koutatsu Shimozono, Toshiyuki Yanai, Tomoko Sasaki, Kota Okabe, Tatsuhiro Shibata, Kazutoshi Mawatari, Tatsuyuki Kakuma, Hiroki Aoki, Yoshihiro Fukumoto   +13 more
doaj   +1 more source