Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis [PDF]
, 2009 Objectives Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene
De Keyser, Filip +8 more
core +1 more source
LTD4 and TGF-β1 induce the expression of metalloproteinase-1 in chronic rhinosinusitis via a cysteinyl leukotriene receptor 1-related mechanism [PDF]
, 2016 A
Bachert, Claus +4 more
core +2 more sources
The Chemokine Receptor CXCR6 Controls the Functional Topography of Interleukin-22 Producing Intestinal Innate Lymphoid Cells [PDF]
Immunity, 2014 Interleukin-22 (IL-22) plays a critical role in mucosal defense, although the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood. We show that the CXCL16-CXCR6 chemokine-chemokine receptor axis regulated group 3 innate lymphoid cell (ILC3) diversity and function.
Satoh-Takayama, Naoko +6 more
openaire +2 more sources
Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]
, 1999 Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C +27 more
core +1 more source
Research advances in understanding the role of interleukin-22 in renal disease
Linchuang shenzangbing zazhi, 2022 Interleukin 22（IL-22），a member of IL-10 cytokine superfamily，is dominantly produced by innate lymphoid cells and CD4+ T helper subtypes such as Th17 and Th22 cells.And interleukin-22 receptor （IL-22R） is a dimer composed of IL-22R1 and IL-10R2 subunit.IL-
Zhao Dan +7 more
doaj
Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress [PDF]
, 2016 It has been demonstrated that immobilization (IMO) stress affects neuroimmune systems followed by alterations of physiology and behavior. Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge ...
An, Kyungeh +4 more
core +4 more sources
Medicine, 2021 Abstract To detect the expression of interlerukin-22 (IL-22) and associated genes and to evaluate their relationship with clinicopathological features and prognosis in laryngeal squamous cell carcinoma (LSCC). The expression of IL-22 and associated genes were evaluated by immunohistochemistry and real time ...
Wenjun Ji +4 more
openaire +2 more sources
Frontiers in Toxicology, 2022 Interleukin 22 (IL-22) is critically involved in gut immunity and host defense and primarily produced by activated T cells. In different circumstances IL-22 may contribute to pathological conditions or act as a cancer promoting cytokine secreted by ...
Yasuhiro Ishihara +10 more
doaj +1 more source
Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22 [PDF]
Immunity, 2013 Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune homeostasis, yet the potential contribution of Trp metabolites from resident microbiota has never been addressed experimentally. Here, we describe a metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice. Switching from sugar
ZELANTE, TERESA +12 more
openaire +5 more sources
Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients
Acta Medica, 1997 The main aim of the present study was a search for a characteristic serum marker of inflammatory activity in the airways of asthmatics with difficult-to-control disease.
Bohuslav Král +6 more
doaj +1 more source