Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia. [PDF]
Infect Immun, 2019 Streptococcus pneumoniae is the most common cause of community-acquired pneumonia worldwide, and interleukin-22 (IL-22) helps contain pneumococcal burden in lungs and extrapulmonary tissues. Administration of IL-22 increases hepatic complement 3 and complement deposition on bacteria and improves phagocytosis by neutrophils. The
Trevejo-Nunez G +11 more
europepmc +4 more sources
Gingival crevicular fluid levels of Interleukin-22 (IL-22) and human β Defensin-2 (hBD-2) in periodontal health and disease : A correlative study. [PDF]
J Oral Biol Craniofac Res, 2020 Interleukin 22(IL-22), a recently identified, Th-22 associated cytokine has a key role in the production of human β defensin-2(hBD-2) and hence an indirect role in innate, nonspecific immunity. Hence this study was conducted as preliminary research to quantify and correlate the levels of IL-22 and hBD-2 in periodontal disease.Gingival crevicular fluid ...
Sidharthan S, Dharmarajan G, Kulloli A.
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Bioengineered, 2022 Alcoholic liver disease (ALD) is a common clinical liver injury disease. Lactobacillus rhamnosus Gorbach-Goldin (LGG) has been revealed to alleviate alcohol-induced intestinal barrier and liver injury. However, the underlying mechanism of LGG treatment for ALD remains unclear. To clarify this aspect, a chronic plus binge ALD model was constructed using
Ge Y +5 more
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Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130. [PDF]
J Biol Chem, 2020 Cytokine signaling is transmitted by cell-surface receptors that function as biological switches controlling mainly immune-related processes. Recently, we have designed synthetic cytokine receptors (SyCyRs) consisting of GFP and mCherry nanobodies fused to transmembrane and intracellular domains of cytokine receptors that phenocopy cytokine signaling ...
Mossner S +6 more
europepmc +3 more sources
Induction of Interleukin-22 (IL-22) production in CD4+ T Cells by IL-17A Secreted from CpG-Stimulated Keratinocytes. [PDF]
Ann Dermatol, 2016 Interleukin-17A (IL-17A) is mainly secreted from Th17 cells that are activated by various stimuli including CpG oligodeoxynucleotide, a Toll-like receptor 9 (TLR9) ligand. Recently, it has been demonstrated that keratinocytes play an important role in the pathogenesis of psoriasis.To investigate the potential role of keratinocytes, we examined whether ...
Li ZJ +8 more
europepmc +4 more sources
Interleukin-22 (IL-22) Regulates Apoptosis of Paclitaxel-Resistant Non-Small Cell Lung Cancer Cells Through C-Jun N-Terminal Kinase Signaling Pathway. [PDF]
Med Sci Monit, 2018 BACKGROUND Reducing drug resistance in tumor cells has become an important issue for cancer treatment. The purpose of this study was to investigate whether IL-22 was involved in lung cancer cell resistance to paclitaxel (PTX), and to explore the underlying molecular mechanism.
Li C +5 more
europepmc +4 more sources
Evaluation of single nucleotide polymorphism in interleukin 22 (IL-22) gene and its association with chronic hepatitis B infection. [PDF]
Gastroenterol Hepatol Bed Bench, 2019 This study aimed to evaluate rs1179251 single nucleotide polymorphism in the IL-22 gene as a host factor and its effect on chronic hepatitis B infection.Interleukin 22 (IL-22) belongs to a group of recently discovered cytokines, and it is produced and secreted by innate lymphoid cells (ILCs) and T helper 22 (Th22) cells.
Asadi P +3 more
europepmc +3 more sources
Identification of the Functional Interleukin-22 (IL-22) Receptor Complex [PDF]
Journal of Biological Chemistry, 2001 Interleukin-10 (IL-10)-related T cell-derived inducible factor (IL-TIF; provisionally designated IL-22) is a cytokine with limited homology to IL-10. We report here the identification of a functional IL-TIF receptor complex that consists of two receptor chains, the orphan CRF2-9 and IL-10R2, the second chain of the IL-10 receptor complex. Expression of
Sergei V. Kotenko +6 more
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Interleukin-22 Influences the Th1/Th17 Axis
Frontiers in Immunology, 2021 Interleukin-22 (IL-22) is secreted by a wide range of immune cells and its downstream effects are mediated by the IL-22 receptor, which is present on non-immune cells in many organs throughout the body.
Hannes Lindahl, Tomas Olsson
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Significance of Interleukin-22 and CD38 in Chronic Lymphocytic Leukemia [PDF]
Minia Journal of Medical Research, 2019 Chronic lymphocytic leukaemia (CLL) is a common type of leukaemia characterised by an abnormal increase in T-cell count. T-helper cytokines were reported to stimulate the survival and proliferation of CLL cells and could be correlated with disease ...
Nancy Youssef +3 more
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