Results 21 to 30 of about 73,008,320 (286)

Serum Interleukin-22 as a Marker of Decompensated Liver Cirrhosis and Hepatocellular Carcinoma in Chronic Hepatitis C Virus Patients [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases
Background and study aim: Chronic liver disease (CLD), when associated with chronic hepatitis C virus (HCV) infection, typically develops into cirrhosis and hepatocellular carcinoma (HCC).
Rania Abou Youssef, Ayman Elshayeb, Akram Deghady, Noura Hosny   +3 more
doaj   +1 more source

The role of interleukin-22 in lung health and its therapeutic potential for COVID-19

Frontiers in Immunology, 2022
Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive.
Si Fang, Dianwen Ju, Yong Lin, Wei Chen, Wei Chen   +4 more
doaj   +1 more source

Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy [PDF]

International Journal of Molecular Sciences, 2019
Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy.
Logiodice F., Lombardelli L., Kullolli O., Haller H., Maggi E., Rukavina D., Piccinni M. P.   +6 more
openaire   +6 more sources

Interleukin-22 promotes the migration and invasion of oral squamous cell carcinoma cells

Immunological Medicine, 2020
The roles of interleukin-22 (IL-22) in carcinogenesis have been proposed in various neoplasms. Increased expression of IL-22 has been observed in oral squamous cell carcinoma (OSCC) lesions as well as in other cancers.
Shihoko Komine-Aizawa, Sohichi Aizawa, Chika Takano, Satoshi Hayakawa   +3 more
doaj   +1 more source

Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation [PDF]

Hepatology, 2004
The central role of T cell activation in hepatocellular injury has been well documented. In this article, we provide evidence suggesting that T cells may also play a protective role in liver disease by releasing interleukin-22 (IL-22), a recently identified T cell-derived cytokine whose biological significance is unclear.
Svetlana, Radaeva, Rui, Sun, Hong-Na, Pan, Feng, Hong, Bin, Gao   +4 more
openaire   +2 more sources

Role of Interleukin-33 in Staphylococcus epidermidis-Induced Septicemia

Frontiers in Immunology, 2020
Interleukin (IL)-33 is a member of the IL-1 family, which plays an important role in inflammatory response. In this study, we evaluated the effect of IL-33 on septicemia and the underlying mechanisms by establishing a Staphylococcus epidermidis (S ...
Min Yang, Yiwen Wang, Yonghong Zhang, Yanjun Li, Qifeng Li, Jintong Tan   +5 more
doaj   +1 more source

Pivotal Role of IL-22 Binding Protein in the Epithelial Autoregulation of Interleukin-22 Signaling in the Control of Skin Inflammation [PDF]

Frontiers in Immunology, 2018
Disruption of skin homeostasis can lead to inflammatory cutaneous diseases resulting from the dysregulated interplay between epithelial keratinocytes and immune cells. Interleukin (IL)-22 signaling through membrane-bound IL-22 receptor 1 (IL-22R1) is crucial to maintain cutaneous epithelial integrity, and its malfunction mediates deleterious skin ...
Tomohiro Fukaya, Tomohiro Fukaya, Takehito Fukui, Takehito Fukui, Tomofumi Uto, Tomofumi Uto, Hideaki Takagi, Hideaki Takagi, Junta Nasu, Junta Nasu, Noriaki Miyanaga, Noriaki Miyanaga, Keiichi Arimura, Keiichi Arimura, Takeshi Nakamura, Takeshi Nakamura, Haruhiko Koseki, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato, Katsuaki Sato   +20 more
openaire   +3 more sources

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Heiko Mühl, Heiko eMühl, Mühl, Heiko
core   +1 more source

Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line [PDF]

Journal of Biological Chemistry, 2002
IL (interleukin)-22 is an IL-10-related cytokine; its main biological activity known thus far is the induction of acute phase reactants in liver and pancreas. IL-22 signals through a receptor that is composed of two chains from the class II cytokine receptor family: IL-22R (also called ZcytoR11/CRF2-9) and IL-10Rbeta (CRF2-4), which is also involved in
Diane Lejeune, Laure Dumoutier, Stefan Constantinescu, Wiebe Kruijer, Jan Jacob Schuringa, Jean-Christophe Renauld   +5 more
openaire   +3 more sources

Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation

Exploration of Immunology, 2021
Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2).
Masutaka Furue, Mihoko Furue
doaj   +1 more source