Interleukin-22, a potent target for treatment of non-autoimmune diseases
Human Vaccines & Immunotherapeutics, 2018 Interleukin −22 (IL-22) is a member of interleukin-10 (IL-10) family cytokines that is produced by different types of lymphocytes included in both innate and adaptive immune systems. These lymphocytes include activated T cells, most notably Th17 and Th22
Yue Zheng, Tong Li
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How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? [PDF]
Journal of Immunology Research, 2016 Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family. It is the only interleukin produced by immune cells but does not target immune system components. IL-22 is mainly produced by dendritic cells (DCs)
Muhammad Babar Khawar +3 more
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PLoS Pathogens, 2016 Interleukin (IL)-22, an immune cell-derived cytokine whose receptor expression is restricted to non-immune cells (e.g. epithelial cells), can be anti-inflammatory and pro-inflammatory.
José L Reyes +7 more
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Targeting interleukin-22 for cancer therapy
Human Vaccines & Immunotherapeutics, 2018 Interleukin-22 (IL-22) is a member of IL-10 family of cytokines. IL-22 induces proliferative and anti-apoptotic signaling pathways and production of anti-microbial molecules that enhance tissue regeneration and host defense.
Anamarija Markota +2 more
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ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints [PDF]
, 2014 Objective. The parasitic worm–derived immunomodulator ES-62 protects against disease in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis (RA) by suppressing pathogenic interleukin-17 (IL-17) responses. The Th17 associated cytokine
Al-Riyami, Lamyaa +4 more
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Characterization of IL-22 Bioactivity and IL-22-Positive Cells in Grass Carp Ctenopharyngodon idella
Frontiers in Immunology, 2020 Interleukin (IL)-22 plays an important role in regulating inflammation and clearance of infectious pathogens. IL-22 homologs have been discovered in fish, but the functions and sources of IL-22 have not been fully characterized.
Yibin Yang +27 more
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Interleukin-22 (IL-22) Production by Pulmonary Natural Killer Cells and the Potential Role of IL-22 during Primary Influenza Virus Infection [PDF]
Journal of Virology, 2010 ABSTRACTWe set out to test the hypothesis that interleukin-22 (IL-22), a cytokine crucial for epithelial cell homeostasis and recovery from tissue injury, would be protective during influenza virus infection. Recent studies have identified phenotypically and functionally unique intestinal NK cells capable of producing the cytokine IL-22.
Hailong, Guo, David J, Topham
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Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study [PDF]
, 2012 Background: Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease.
Stefan Zeuzem +35 more
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Food Science of Animal Resources, 2023 It is known that animal-origin medicine could be one of effective treatment to remedy atopic dermatitis (AD) by controlling the cytokines. Cicadidae Periostracum (CP), the slough of Cryptotympana pustulata, has been frequently used for treating AD and ...
Ganghye Park +3 more
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Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1 [PDF]
, 2010 If insufficiently treated, Lyme borreliosis can evolve into an inflammatory disorder affecting skin, joints, and the CNS. Early innate immunity may determine host responses targeting infection. Thus, we sought to characterize the immediate cytokine storm
Nicole Darsow +38 more
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