Results 231 to 240 of about 615,879 (297)

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Biomarkers and Endothelial Damage in Obesity: An Insight into the Pharmacological Modulation. [PDF]

Int J Mol Sci
Bojórquez-González AY, Gómez-Sánchez E, Suarez-Rico DO, Beltrán-Ramírez A, Balleza-Alejandri LR, López-Murillo LD, Ramírez-Lizardo EJ, García-Galindo JJ.   +7 more
europepmc   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Cardiovascular risk in primary aldosteronism: inflammatory drivers, residual risk, and emerging combination strategies. [PDF]

Front Endocrinol (Lausanne)
Liu H, Wu Z, Liu X, Hu Y, Zhang K, Shang J.   +5 more
europepmc   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Myo-inflam: a mini review on inflammatory pathways driving scleral remodeling and axial elongation. [PDF]

Front Immunol
Lin B, Liang W, Cai LR, Xu M, Li DK.
europepmc   +1 more source

Tryptophan Indole Metabolites Reduce Anastomotic Leakage Through Aryl Hydrocarbon Receptor-driven Interleukin-22 Production

Cellular and Molecular Gastroenterology and Hepatology
Vasiliki Bantavi, Laura Gloeck, Patrick Leven, Konstantina Zafeiropoulou, Olaf Welting, Hilal Sengül, Patrik Efferz, Bianca Schneiker, Timothy Ryan McCulloch, Christoph Wilhelm, Sandra Blaess, Anneke Fuss, Joep P.M. Derikx, Bruno Sovran, Wouter J. de Jonge, Sven Wehner, Jan Stoot, Joop Konsten, Nicole Bouvy   +18 more
openaire   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

T cell-mediated immunodysregulation in multiple sclerosis: from pathogenic subsets to therapeutic advances. [PDF]

Front Immunol
Wang Z, Han D, Qiao X, Zhao X, Zhao C, Liu S, Tao R, Jin M, Qu P.   +8 more
europepmc   +1 more source

Faculty Opinions recommendation of The pathogenic role of interleukin-22 and its receptor during UVB-induced skin inflammation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2017
openaire   +2 more sources