Results 261 to 270 of about 615,879 (297)

Temporal expression of interleukin‐22, interleukin‐22 receptor 1 and interleukin‐22‐binding protein during experimental periodontitis in rats

Journal of Periodontal Research, 2017
Background and ObjectiveInterleukin‐22 (IL‐22), mainly produced by CD4+ T‐helper subtypes and innate lymphoid cells at barrier surfaces, is found to involve in several diseases, including diabetes, rheumatoid arthritis, peri‐implantitis and chronic rhinosinusitis with nasal polyps.
S. Pan, D. Yang, J. Zhang, Z. Zhang, H. Zhang, X. Liu, C. Li   +6 more
openaire   +2 more sources

Comparison of Interleukin-22 and Interleukin-10 Soluble Receptor Complexes

Journal of Interferon & Cytokine Research, 2002
Interleukin-22 (IL-22) is a cellular homolog of IL-10 that stimulates the production of acute-phase reactants. IL-22 and IL-10 require different ligand-specific receptor chains (IL-22R and IL-10R1) but share a second receptor chain (IL-10R2) to initiate cellular responses.
Naomi J, Logsdon, Brandi C, Jones, Kristopher, Josephson, Jennifer, Cook, Mark R, Walter   +4 more
openaire   +2 more sources

Interleukin-22 receptor signaling in Paneth cells is critical for their maturation and antimicrobial function

The Journal of Immunology, 2020
Abstract Interleukin-22 (IL-22) acts in the intestine to promote critical tissue protective functions. However, since a diverse array of intestinal cell types (absorptive, secretory, and stem cells) express IL-22Ra1, a receptor for IL-22, it has been difficult to determine what cell type(s) specifically respond to IL-22 to mediate ...
Stephen Gaudino, Michael Beaupre, Xun Lin, Sonika Rathi, Patrick McLaughlin, Neil Mehta, Onur Eskiocak, Brian Yueh, Adrianus Van der Velden, Semir Beyaz, Pawan Kumar   +10 more
openaire   +1 more source

Pancreatic Interleukin-22 Receptor Signaling is Critical in Maintaining Beta-Cell Insulin Production and is Hepatoprotective

The Journal of Immunology, 2022
Abstract We discovered that the cytokine interleukin-22 (IL-22) is an efficient natural inhibitor of cellular stress and exogenous IL-22 improved insulin quality in pancreatic β-cells in preclinical models of Type 2 diabetes. Importantly, IL-22 completely restored glucose tolerance, suppressed fasting hyperinsulinemia/hyperproinsulinemia,
Sajiir, Haressh, Wong, Kuan Yau, Mueller, Alexandra, Keshvari, Sahar, Wang, Ran, Wiid, Percival, Macdonald, Graeme, Prins, John, McGuckin, Michael A., Hasnain, Sumaira Z.   +9 more
openaire   +2 more sources

Soluble Receptors of the Interleukin-10 Family of Cytokines: Interleukin-22 Receptor Alpha 2

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2006
The interleukin (IL)-10 family of cytokines comprising IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28α, IL- 28β, and IL-29 uses receptors of the cytokine receptor family class 2. Here we review the current knowledge about IL-22 receptor-α2 (IL-22Rα2) which is the first known soluble receptor of that cytokine family.
R. Sabat, E. Wallace, K. Asadullah, W. Sterry, H.-D. Volk, K. Wolk   +5 more
openaire   +1 more source

The role of Interleukin-22 and its receptor Interleukin-22Rα on the regulation of inflammatory responses in the brain

The Journal of Immunology, 2020
Abstract Interleukin (IL)-22 is a member of IL-10 family, is a potent mediator of inflammatory responses. It is produced by activated CD4+ T cells and natural killer (NK) cells and takes effect on non-hematopoietic cells mainly stromal and epithelial cells. And, IL-22 receptor consists of IL-22Rα and IL-10Rβ.
DaHae Lee, Yejin Kim, Hyejung Jo, Jae Seung Kang   +3 more
openaire   +1 more source

Polymorphisms in the interleukin‐22 receptor alpha‐1 gene are associated with severe chronic rhinosinusitis

Otolaryngology–Head and Neck Surgery, 2009
RationaleStimulation of interleukin‐22 receptor alpha‐1 (IL22RA1) was reported to increase the innate immune responses in inflammatory diseases. Moreover, a reduced level of IL22RA1 was found in patients with recalcitrant CRS with nasal polyps.ObjectiveTo explore association between single nucleotide polymorphisms (SNPs) in IL22RA1 and severe CRS ...
Leandra Mfuna, Endam, Yohan, Bossé, Abdelali, Filali-Mouhim, Chantale, Cormier, Pierre, Boisvert, Louis-Philippe, Boulet, Thomas J, Hudson, Martin, Desrosiers   +7 more
openaire   +2 more sources

Chronic Rhinosinusitis With Nasal Polyps is Associated With Decreased Expression of Mucosal Interleukin 22 Receptor

The Laryngoscope, 2007
AbstractIntroduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disorder of the sinonasal mucosa that is frequently associated with microbial colonization. Innate defense mechanisms at the mucosal surface are critical in protecting the host from airborne environmental pathogens.
Murugappan, Ramanathan, Ernst W, Spannhake, Andrew P, Lane   +2 more
openaire   +2 more sources

High Expression of Interleukin-22 and Its Receptor Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma

Annals of Surgical Oncology, 2013
The cytokine interleukin-22 (IL-22) and its receptor are present in the tumor microenvironment. Their function in pancreatic ductal adenocarcinoma (PDAC) remains largely unknown. The goal of the present study was to measure the expression of IL-22 and IL-22R in PDAC and assess their relationship with clinicopathological features and prognosis.The ...
Zhang, Wen, Quan, Liao, Jianguo, Zhao, Ya, Hu, Lei, You, Zhaohui, Lu, Congwei, Jia, Yingxin, Wei, Yupei, Zhao   +8 more
openaire   +2 more sources