Results 231 to 240 of about 517,111 (322)

The use of interleukin 23 inhibitors in patients with chronic hepatitis B infection: A case series. [PDF]

JAAD Case Rep, 2022
Ch'en PY, Farrer S, Miranda-Cacdac L, Song EJ.   +3 more
europepmc   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Translational Pharmacokinetics of Icotrokinra, a Targeted Oral Peptide that Selectively Blocks Interleukin-23 Receptor and Inhibits Signaling. [PDF]

Dermatol Ther (Heidelb)
Knight B, Tammara B, Modi NB, Dallas S, Mardirosian S, Wang J, Laenen A, Leclercq L, DiLoreto K, Adriaenssen L, Moss D, Polidori D, Chaudhuri SR, Park S, Sensenhauser C, Ndifor A, Sukumaran S, Baguet T, Shi Y, Patel S, Geist B, Fourie A, Patch R, Sun C, Barros SA, Somani S, Monshouwer M.   +26 more
europepmc   +1 more source

Interleukin-23 receptor defines T helper 1-like regulatory T cells in oral squamous cell carcinoma. [PDF]

Immun Inflamm Dis, 2022
Li W, An N, Wang M, Liu X, Mei Z.
europepmc   +1 more source

Interleukin‐23 Secreted by Activated Macrophages Drives γδT Cell Production of Interleukin‐17 to Aggravate Secondary Injury After Intracerebral Hemorrhage

, 2016
Qi Zhong, Kai Zhou, Qiaoli Liang, Sen Lin, Yanchun Wang, Xiao‐Yi Xiong, Zhaoyou Meng, Ting Zhao, Wenyao Zhu, Yuan‐Rui Yang, Mao‐Fan Liao, Qiuwen Gong, Liang Liu, Ao Xiong, Junwei Hao, Jian Wang, Qingwu Yang   +16 more
openalex   +1 more source

The role of the interleukin‐23/Th17 pathway in cardiometabolic comorbidity associated with psoriasis

, 2020
Alexander Egeberg, Paolo Gisondi, J.M. Carrascosa, Richard B. Warren, Ulrich Mrowietz   +4 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Combination of mechanical debridement and interleukin 12 or interleukin 23 therapy for refractory facial pyoderma gangrenosum with NOD2 mutation. [PDF]

JAAD Case Rep
Vague M, Shea M, Thacker S, Onoday H, Ortega Loayza AG.   +4 more
europepmc   +1 more source

Interleukin-23 in the Pathogenesis of Inflammatory Bowel Disease and Implications for Therapeutic Intervention. [PDF]

J Crohns Colitis, 2022
Sewell GW, Kaser A.
europepmc   +1 more source

Interleukin 23 in IBD Pathogenesis

, 2016
Eken, Ahmet, Oukka, Mohamed
openaire   +3 more sources