Results 261 to 270 of about 517,111 (322)

Crohn's Disease Associated With IgA Nephropathy Effectively Treated With the Interleukin-23 Inhibitor Risankizumab. [PDF]

ACG Case Rep J
Larson C, Munir N, Rao P, Farkash E, Kathuria P, Romain D, Berinstein J.   +6 more
europepmc   +1 more source

Growth abnormalities of fetuses and infants [PDF]

, 2017
Cosmi, Erich, Fanos, Vassilios, Grisan, Enrico, Rizzo, Giuseppe, Sivanandam, Shanthi, Visentin, Silvia   +5 more
core   +3 more sources

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Metabolic Stress Expands Polyfunctional, Proinflammatory Th₁₇ Cells in Patients With Psoriatic Arthritis for Whom There is Interleukin-23-Independent Interleukin-17 Production. [PDF]

Arthritis Rheumatol
Stober CB, Ellis L, Goodall JC, Veldhoen M, Gaston JSH.   +4 more
europepmc   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Reduction of Serum Interleukin-17 and Interleukin-23 Levels Following Narrow Band Ultraviolet B Treatment in Patients with Moderate-to-severe Psoriasis Vulgaris. [PDF]

Mater Sociomed
Phuong PTM, Huyen TT, Giang QTH, Trang TM, Phuong HT, Yen LTH, Thuong NV, Doanh LH.   +7 more
europepmc   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Interleukin-23 levels in umbilical cord blood are associated with neurodevelopmental trajectories in infancy. [PDF]

PLoS One
Asaka MK, Nishimura T, Kuwabara H, Itoh H, Takahashi N, Tsuchiya KJ.   +5 more
europepmc   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Interleukin-21 and Interleukin-23 levels in familial Mediterranean Fever before and after treatment: the role of cytokines in disease pathogenesis. [PDF]

Sci Rep
Hizal M, Tufan A, Mercan R, Pasaoglu OT, Pasaoglu H, Haznedaroglu S, Goker B, Ozturk MA.   +7 more
europepmc   +1 more source