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Microglia express a functional receptor for interleukin-23
Biochemical and Biophysical Research Communications, 2008Interleukin (IL)-23 plays a predominant role in the development of autoimmune diseases by inducing IL-17-producing helper T (Th17) cells. The receptor for IL-23 consists of a heterodimer composed of the IL-12 receptor beta1 (IL-12Rbeta1) and the IL-23 receptor (IL-23R), which is mainly expressed on Th17 cells.
Yoshifumi, Sonobe +6 more
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An emerging role of interleukin-23 in rheumatoid arthritis
Immunopharmacology and Immunotoxicology, 2019Rheumatoid arthritis (RA) is an autoimmune, chronic inflammatory disease and is characterized by destruction of the articular cartilage. A number of pro-inflammatory cytokines work sequentially and in concert with one another to induce the development of RA.
Na, Yuan +4 more
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Regulation of Memory T Cells by Interleukin-23
International Archives of Allergy and Immunology, 2016Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-
Yanchun, Li +3 more
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Interleukin-23: Immunological roles and clinical implications
The International Journal of Biochemistry & Cell Biology, 2009Increasing evidence has revealed the importance of IL-23, which closely resembles IL-12 both structurally and immunologically, in linking innate and adaptive immunity. IL-23, produced by activated type 1 macrophages and dendritic cells (DC), possesses unique roles in the differentiation and expansion of memory T cells.
Zi Yan, Tan +4 more
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Pathophysiology of Interleukin-23 in Experimental Autoimmune Encephalomyelitis
Drug News & Perspectives, 2006Interleukin-23 (IL-23) is a heterodimeric cytokine that is composed of a p40 subunit, shared with the closely related cytokine IL-12, and a smaller IL-23p19 subunit. It belongs to a family of heterodimeric cytokines that also includes IL-12 and IL-27.
Tarik, Touil +4 more
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Interleukin-23 as a potential therapeutic target for rheumatoid arthritis
Molecular and Cellular Biochemistry, 2011Cytokine-mediated immunity plays a crucial role in the pathogenesis of various autoimmune diseases, including rheumatoid arthritis (RA). Increasing evidence has revealed the importance of IL-23, which closely resembles IL-12 structurally and immunologically, in linking innate and adaptive immunity.
Chao, Rong +4 more
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Sarcopenia and interleukin-23 in colorectal cancer survival
Clinical Nutrition, 2022Shupeng, Gao, Yan, Li
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Interleukin-23 in the pathogenesis and treatment of psoriasis.
Skin therapy letter, 2016In the past three decades, major advances have been made in understanding the pathogenesis of psoriasis. The currently accepted theory is that T-cell mediated immune dysregulation triggers keratinocyte hyperproliferation in psoriasis. Recent research indicates that the Th17/interleukin (IL)-23 pathway plays a prominent role in the amplification phase ...
Ramya, Kollipara +3 more
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