Results 1 to 10 of about 60,435,326 (243)

Interleukin-23 Inhibitors

Turkderm Turkish Archives of Dermatology and Venereology, 2022
For adult patients with moderate to severe plaque psoriasis scheduled for systemic therapy, FDA-approved agents that act via interleukin-23 (IL-23) inhibition are guselkumab, tildrakizumab, and risankizumab.
Esra Adışen
doaj   +4 more sources

Efficacy of interleukin-12/23 and interleukin-23 inhibitors in Hailey-Hailey disease [PDF]

JAAD Case Reports
Caroline Echeandia-Francis, BA, Xingyuan Jiang, MD, Ryland D. Mortlock, BS, Mohamad Goldust, MD, Leonard M. Milstone, MD, Keith A. Choate, MD, PhD   +5 more
doaj   +4 more sources

Levels of IL-23/IL-17 Axis in Plasma and Gingival Tissue of Periodontitis Patients According to the New Classification

Applied Sciences, 2022
Background: Periodontitis (P) is a chronic inflammatory disease characterized by the destruction of periodontium support tissue generated by different immuno-inflammatory mechanisms, including the RANK/RANKL/OPG and the IL-23/IL-17 axis.
Ruth Rodríguez-Montaño, Alondra del Carmen Ruiz-Gutiérrez, Vianeth María del Carmen Martínez-Rodríguez, Juan Ramón Gómez-Sandoval, Juan Manuel Guzmán-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velázquez   +7 more
doaj   +1 more source

Circulating Interleukin-23 Levels in Rheumatoid Arthritis and its Relationship to Disease Activity: a Systematic Review with Meta-Analysis

مجله كليه طب الكندي, 2023
Background: Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease that is characterized by severe synovial inflammation, cartilage erosion, bone loss, and generalized vasculopathy.
Ahmed Azzam, Shaza Abdul Basset Abdul Basset, Heba Khaled, Neveen Refaey, Ahmed Atta Ahmed Ali, Saad abdelrahim saad shoulah, Mohammed Saleh Al Saifi, Mahmoud s.Meleha   +7 more
doaj   +1 more source

Interleukin 23 in Crohnʼs Disease [PDF]

Inflammatory Bowel Diseases, 2014
: Crohn's disease (CD) is a lifelong inflammatory condition with underlying environmental and genetic components. CD affects multiple parts of the gastrointestinal tract, and it has a growing incidence in Western societies. IL-23 receptor variants have been identified as susceptibility or resistance factors for CD in genome-wide association studies ...
Oukka, Mohamed, Eken, Ahmet, Singh, Akhilesh K.   +2 more
openaire   +3 more sources

Decoding IL-23 Signaling Cascade for New Therapeutic Opportunities

Cells, 2020
The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis, or rheumatoid arthritis.
Gloria Pastor-Fernández, Isabel R. Mariblanca, María N. Navarro   +2 more
doaj   +1 more source

Prospects for the use of monoclonal antibodies to interleukin 23 Gusеlkumab in psoriatic arthritis: New data

Научно-практическая ревматология, 2022
Among the pathophysiological mechanisms of immune-mediated inflammatory diseases (IMIDs), specific attention has been paid to the abnormal activation of Th17 type immune response related to the dysregulated synthesis of cytokines forming the interleukin (
E. L. Nasonov, T. V. Korotaeva, S. Rodolfi, C. F. Selmi   +3 more
doaj   +1 more source

The interleukin-23/interleukin-17 axis in spondyloarthritis [PDF]

Current Opinion in Rheumatology, 2008
To inform readers of recent advances in our understanding of the development and function of Th17 T cells and emerging data suggesting that the interleukin-23/interleukin-17 axis may be involved in the pathogenesis of spondyloarthritis.The discovery of CD4+ Th17 T cells and the interleukin-23/interleukin-17 axis has challenged existing paradigms and ...
Gerlinde, Layh-Schmitt, Robert A, Colbert   +1 more
openaire   +2 more sources

Current concepts in the pathogenesis of spondyloarthritis

Indian Journal of Rheumatology, 2020
Pathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us ...
Nibha Jain, Arumugam Moorthy
doaj   +1 more source

Interleukin 23 Levels Are Increased in Carotid Atherosclerosis [PDF]

Stroke, 2015
Background and Purpose— Interleukin (IL)-23 is a cytokine in the IL-12 family, mainly produced by antigen-presenting cells with a central role in inflammation. We hypothesize that IL-23 is also important in atherogenesis and investigate this in a population with carotid atherosclerosis. Methods—
Abbas, Azhar, Gregersen, Ida, Holm, Sverre, Daissormont, Isabelle, Bjerkeli, Vigdis, Krohg-Sorensen, Kirsten, Skagen, Karolina R., Dahl, Tuva B., Russell, David, Almas, Trine, Bundgaard, Dorte, Alteheld, Lars Holger, Rashidi, Azita, Dahl, Christen P., Michelsen, Annika E., Biessen, Erik A., Aukrust, Pal, Halvorsen, Bente, Skjelland, Mona   +18 more
openaire   +3 more sources