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Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading
Advanced Science, EarlyView.Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong +5 more
wiley +1 more source
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The Immunobiology of Interleukin-27
Annual Review of Immunology, 2015Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now recognized as a potent antagonist of different classes of inflammation through its ability to directly modify CD4+and CD8+T cell effector functions, to induce IL-10, and to ...
Hiroki, Yoshida, Christopher A, Hunter
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Antitumor Activities of Interleukin-27 on Melanoma
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2010The worldwide incidence of malignant melanoma has been steadily increasing, and it has become a major public health problem in many countries. Melanoma has been considered as a prototypical "immunogenic" tumor on the basis of clinical observations showing that primary lesions can spontaneously regress and that immunosuppressed individuals have an ...
Hiroshi, Nagai +6 more
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The Role of Interleukin-27 in Atherosclerosis: A Contemporary Review
Cardiology, 2021Atherosclerosis is a chronic inflammation characterized by an imbalance between inhibitors and stimulators of the inflammatory system that leads to the formation of atherosclerotic plaques in the vessel walls. Interleukin (IL)-27 is one of the recently discovered cytokines that have an immunomodulatory role in autoimmune and inflammatory diseases ...
Mehrian Jafarizade +7 more
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Regulation of immune responses by interleukin‐27
Immunological Reviews, 2008Summary: Cytokine‐mediated immunity plays a crucial role in the pathogenesis of various diseases including autoimmunity. Recently, interleukin‐27 (IL‐27) was identified, which, along with IL‐12, IL‐23, and IL‐35, belongs to the IL‐12 cytokine family. These family members play roles in the regulation of T helper (Th) cell differentiation.
Hiroki, Yoshida +2 more
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The biology and therapeutic potential of interleukin 27
Journal of Molecular Medicine, 2007Interleukin (IL-) 27 is a helical cytokine of the greater IL-6/IL-12 family with a broad range of pro- and anti-inflammatory properties. It can skew T helper cell development, suppress T cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B cells, and has diverse effects on innate immune cells.
Marcel, Batten, Nico, Ghilardi
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The immunomodulatory potentials of interleukin‐27 in airway allergies
Scandinavian Journal of Immunology, 2020AbstractAllergic airway disorders such as asthma and allergic rhinitis are mainly caused by inhaled allergen‐induced improper activation and responses of immune and non‐immune cells. One important response is the production of IL‐27 by macrophages and dendritic cells (DCs) during the early stage of airway allergies.
Abdollah Jafarzadeh +4 more
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Interleukin 27 attenuates collagen-induced arthritis
Annals of the Rheumatic Diseases, 2008To investigate the potential role of interleukin (IL) 27 in rheumatoid arthritis (RA) by examining the expression of IL27 in the articular joints of patients with RA and the effect of recombinant IL27 in vivo in a murine model of collagen-induced arthritis (CIA).Synovial membranes from patients with RA were examined for the presence of IL27 by ...
W, Niedbala +6 more
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Interleukin-27: Biological Properties and Clinical Application
Archivum Immunologiae et Therapiae Experimentalis, 2010Interleukin (IL)-27 is a novel cytokine secreted by stimulated antigen-presenting cells. Initial studies on the biology of IL-27 provided evidence for its role in the initiation of T(H)1 responses; however, subsequent work has indicated that IL-27 has broad inhibitory effects on T(H)1, T(H)2, and T(H)17 subsets of T cells as well as the expansion of ...
Marek, Jankowski +2 more
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Expression of Interleukin-27 by Human Trophoblast Cells
Placenta, 2007Cytokines produced at the fetal-maternal interface play a key role in regulating maternal tolerance to the fetus and successful pregnancy. Previously, we showed that EBV-induced gene 3 (EBI3), an interleukin (IL)-12 p40 homologue, was expressed at very high levels by syncytiotrophoblasts and extravillous trophoblasts throughout human pregnancy.
Coulomb-L'Hermine, A. +5 more
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