Results 251 to 260 of about 62,501,450 (280)

The pathogenic role of interleukin-27 in autoimmune diabetes

Cellular and Molecular Life Sciences, 2008
Interleukin (IL)-27 is an IL-12-related cytokine that can promote both anti- and pro-inflammatory immune responses. This study investigated the potential role of IL-27 in autoimmune diabetes. We detected a high level of IL-27 in diabetic NOD mice. In addition, blockade of IL-27 significantly delayed the onset of diabetic splenocyte-transferred diabetes,
R, Wang, G, Han, J, Wang, G, Chen, R, Xu, L, Wang, X, Li, B, Shen, Y, Li   +8 more
openaire   +2 more sources

Research Progress of Interleukin-27 in Inflammatory Bowel Disease

Inflammatory Bowel Diseases, 2023
Abstract Inflammatory bowel disease (IBD) can be identified as an inflammatory disorder in the intestine, being characterized by maladjusted immune responses and chronic inflammation of the intestinal tract. However, as the etiology and pathogenesis are still unclear, more effective therapeutic approaches are needed.
Qing Wang, Feifan Chen, Yingqiu Peng, Xuanyu Yi, Yu He, Yuan Shi   +5 more
openaire   +2 more sources

Elevated levels of interleukin-27 in patients with Sjögren's syndrome

Scandinavian Journal of Rheumatology, 2011
Primary Sjogren’s syndrome (pSS) is a systemic autoimmune disorder characterized by lymphocytic infiltration and progressive destruction of exocrine glands, such as the salivary and lachrymal gland...
L, Xia, H, Shen, L, Zhao, J, Lu
openaire   +2 more sources

Association between interleukin-27 polymorphisms and pulmonary tuberculosis

The International Journal of Tuberculosis and Lung Disease, 2015
To investigate the effect of interleukin (IL) 27 -964A/G, 2095T/G, 4603G/A and 4730T/C gene polymorphisms on the development of pulmonary tuberculosis (PTB), radiographic characteristics and severity.Differences in the allele and genotype distributions of the -964A/G, 2095T/G, 4603G/A and 4730T/C polymorphisms between 224 PTB patients and 233 healthy ...
J Y, Oh, J K, Sim, W J, Jung, K H, Min, E J, Lee, G Y, Hur, S Y, Lee, S Y, Lee, A M, Kwon, J H, Kim, C, Shin, J J, Shim, K H, In, K H, Kang, S H, Lee   +14 more
openaire   +2 more sources

Interleukin‐27 as a Negative Regulator of Human Neutrophil Function

Scandinavian Journal of Immunology, 2010
AbstractInterleukin‐27 (IL‐27) is a novel cytokine of the IL‐6/12 family with a broad range of immune regulation properties, which has been considered as a potential therapeutic agent for immune diseases and cancers. However, little is known about the effect of IL‐27 on human neutrophils before its clinical administration.
J P, Li, H, Wu, W, Xing, S G, Yang, S H, Lu, W T, Du, J X, Yu, F, Chen, L, Zhang, Z C, Han   +9 more
openaire   +2 more sources

Interleukin-27 Mediates Inflammation During Chronic Disease

Journal of Interferon & Cytokine Research, 2014
The interleukin (IL)-12 family cytokine, IL-27 has been implicated in the pathogenesis of many autoimmune inflammatory disorders, including rheumatoid arthritis, psoriasis, multiple sclerosis, Crohn's disease, and ulcerative colitis. Discovered in 2002, IL-27 has been primarily described as an anti-inflammatory cytokine with regulatory roles in ...
Christopher, Wynick, Carlene, Petes, Katrina, Gee   +2 more
openaire   +2 more sources

[Progress on interleukin-27 in tumor immunity].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2015
As a member of IL-6/IL-12 cytokine family, IL-27 is a heterodimeric cytokine composed of the p28 and EBI3. Functioning as a linkage between innate and adaptive immunity, IL-27 is mainly produced by activated antigen-presenting cells and has a variety of responder cells including T cells, NK cells, macrophages and dendritic cells.
Jia, He, Qing-qing, Wang
openaire   +1 more source

Interleukins in Cancer: From Biology to Therapy

Nature Reviews Cancer, 2021
Peter Libby, Daria Briukhovetska, Stefan Endres   +2 more
exaly  

Interleukin 27

2014
Marcel Batten, Dipti Vijayan
openaire   +1 more source

Potentent antitumor activity of interleukin-27.

2004
Although much promising data that interleukin (IL)-12 could be a powerful therapeutic agent against cancer were reported in animal models, its excessive toxicity has become a problem for its clinical application. IL-27 is a novel IL-12 family member that plays a role in the early regulation of T helper cell 1 initiation, including induction of T-bet ...
Hisada M., Kamiya S., Fujita K., BELLADONNA, Maria Laura, Aoki T., Koyanagi Y., Mizuguchi J., Yoshimoto T.   +7 more
openaire   +1 more source