Results 51 to 60 of about 62,501,450 (280)

Serum IL-27 and IL-35 Levels as Complementary Biomarkers of Immune Status in HIV-Positive Individuals

Cyprus Journal of Medical Sciences
BACKGROUND/AIMS: Human immunodeficiency virus (HIV) infection remains a worldwide public health challenge, primarily due to its disruption of immune regulation and cytokine homeostasis.
Mine Büşra Bozkürk, Büşra Merve Yıldırım, Nesibe Korkmaz, Canan Topçuoğlu, Gönül Çiçek Şentürk, Alpaslan Öztürk, Ergül Bayram   +6 more
doaj   +1 more source

Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model

Biology, 2022
A treatment with direct healing effects on the gastrointestinal epithelial barrier is desirable for inflammatory bowel disease (IBD). Interleukin-27 (IL-27) is an immunoregulatory cytokine, and oral delivery is an effective treatment in murine models of ...
Daniel P. Brice, Graeme I. Murray, Heather M. Wilson, Ross J. Porter, Susan Berry, Scott K. Durum, Mairi H. McLean   +6 more
doaj   +1 more source

The effects of anti-interleukin-5 on SABA rescue use.

, 2016
The effects of anti-interleukin-5 on SABA rescue use.
Ting Liu (45625), Fa-Ping Wang (3358667), Hui Mao (115181), Zhu Lan (3358673), Su-Yun Li (3358670)   +4 more
core   +1 more source

New directions in the basic and translational biology of interleukin-27 [PDF]

Trends in Immunology, 2012
Interleukin (IL)-27 is a member of the IL-6 and IL-12 family composed of the IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3) subunits. Although IL-27 was originally identified as a proinflammatory factor, subsequent studies have revealed the pleiotropic nature of this cytokine.
Elia D Tait, Wojno, Christopher A, Hunter   +1 more
openaire   +2 more sources

Interleukin-27 suppresses osteoclastogenesis via induction of interferon-γ

, 2012
Interleukin (IL)-27 is a heterodimeric cytokine that is known to have both stimulatory and inhibitory functions during immune responses. We investigated the effects of IL-27 on arthritis and bone erosion in the murine collagen-induced arthritis (CIA ...
Kim, HY, Kang, CM, Park, SH, Jung, YO, Kwok, SK, Park, SJ, Oh, HJ, Ju, JH, Sung, YC, Cho, ML, Park, JS, Heo, YJ, Park, KS, Young-Chul Sung, Chang-Min Kang, Hye-Joa Oh, Ji Hyeon Ju, Ho-Youn Kim, Seong Jeong Park, Sung-Hwan Park, Mi-La Cho, Jin-Sil Park, Seung-Ki Kwok, Kyung Su Park, Yu-Jung Heo, Young Ok Jung   +25 more
core   +1 more source

Lack of Association between Serum Interleukin-23 and Interleukin-27 Levels and Disease Activity in Patients with Active Systemic Lupus Erythematosus

, 2021
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of multiple autoantibodies, resulting in tissue and organ damage.
Katarzyna Pawlak-Buś, Wiktor Schmidt, Piotr Leszczyński   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Impact of angiotensin converting enzyme inhibition on post- coronary artery bypass interleukin 6 release [PDF]

, 2002
Background: Angiotensin 1 converting enzyme (ACE) inhibitors reduce morbidity and mortality after coronary artery bypass graft surgery (CABG). This benefit may result from an anti- inflammatory action.
Humphries, S.E., Rumley, A., Lowe, G.D., Montgomery, H.E., Sanders, J., Brull, D.J.   +5 more
core   +6 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]

, 2000
By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
Stäheli, Peter, Peter Staeheli, Staeheli, Peter, Baeuerle, Patrick A., Kaspers, Bernd, Kirsten Schneider, Schneider, Kirsten, Baeuerle, Daniela, Daniela Baeuerle, Kirsten C. Weining, Puehler, Florian, Elvers, Sandra, Weining, Kirsten C., Florian Puehler, Sandra Elvers, Bernd Kaspers   +15 more
core   +1 more source